Regulatory Effect of Cannabinoid Receptor Agonist on Chemokine-Induced Lymphocyte Chemotaxis
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概要
- 論文の詳細を見る
Cannabinoids elicit biological responses through two types of specific receptors, CB1 and CB2. Immune cells including naïve B-lymphocytes are known to selectively express peripheral cannabinoid receptors, CB2. Although the immunosuppressive effects of cannabinoids have become widely known, the mechanisms underlying their effects are not well understood. In this study, we demonstrated that splenic lymphocytes migrated toward a synthetic cannabinoid receptor agonist, WIN55,212-2. There is an optimal concentration range for induction of lymphocyte migration and a high dose fails to induce cell migration. Furthermore, a high dose of WIN55,212-2 significantly inhibited CXCL12-induced chemotaxis of lymphocytes. The inhibitory effect was transient and reversible. The inhibition was also observed when purified B-lymphocytes were used for CXCL12-induced chemotaxis. These results provide novel information regarding the cellular mechanisms underlying the effects of cannabinoids on the immune system.
- 公益社団法人 日本薬学会の論文
著者
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Tanikawa Takashi
Laboratory of Microbiology and Immunology and the Global COE Program, University of Shizuoka School
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Kurohane Kohta
Laboratory of Microbiology and Immunology and the Global COE Program, University of Shizuoka School
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Imai Yasuyuki
Laboratory of Microbiology and Immunology and the Global COE Program, University of Shizuoka School
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Kurohane Kohta
Department Of Microbiology And Coe Program In The 21st Century University Of Shizuoka School Of Phar
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Kurohane Kohta
Laboratory Of Microbiology And Immunology And Coe Program In The 21st Century University Of Shizuoka
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Imai Yasuyuki
Laboratory Of Microbiology And Immunology And Coe Program In The 21st Century University Of Shizuoka
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Imai Yasuyuki
Laboratory of Microbiology and Immunology and The Global COE Program, School of Pharmaceutical Sciences, University of Shizuoka
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Kurohane Kohta
Laboratory of Microbiology and Immunology and the Global COE Program, School of Pharmaceutical Sciences, University of Shizuoka
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Tanikawa Takashi
Laboratory of Microbiology and Immunology and The Global COE Program, School of Pharmaceutical Sciences, University of Shizuoka
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Tanikawa Takashi
Laboratory of Microbiology and Immunology and COE Program in the 21st Century, University of Shizuoka School of Pharmaceutical Sciences
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