Altered Leukocyte Responsiveness in Dairy Cows with Naturally Occurring Chronic Staphylococcus aureus Mastitis
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概要
- 論文の詳細を見る
Changes in inflammatory parameters, leukocyte surface markers, functional responses and cytokine mRNA expression of leukocytes from dairy cows with naturally occurring chronic Staphylococcus aureus (S. aureus) mastitis and healthy cows were determined to elucidate the leukocyte responses to S. aureus infection of the mammary gland. Increased values in inflammatory parameters and matrix metalloproteinase activities in milk revealed the characteristics of cows with chronic mastitis. Expression of L-selectin and CD18 molecules on neutrophils and proportion of CD8 cells in milk from cows with S. aureus mastitis were significantly (P<0.05) increased compared to those found in healthy cows. The FcR-stimulated CL response of blood neutrophils was significantly (P<0.05) decreased in cows with S. aureus mastitis. Significantly (P<0.05) decreased mitogenic responses of lymphocytes were found in cows with S. aureus mastitis; however, the values were not restored to those of healthy cows when stimulated with both mitogens and the cytokine IL-1β. mRNA expression of the TNF-α, IL-1β and IL-8 on milk leukocytes from cows with S. aureus was found to be increased compared to that of healthy cows. The changes of immune responses found in cows with S. aureus mastitis appear to be influenced by the severity and duration of inflammation in infected quarters. The down-regulation of the leukocyte functions found in cows with S. aureus mastitis appears to be associated with the progress of the chronic stage of S. aureus mastitis.
著者
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Kawai Kazuhiro
Department Of Anatomy And Cell Biology:medical And Dental University
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Nagahata Hajime
Department Of Animal Health School Of Veterinary Medicine Rakuno Gakuen Univeristy
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Higuchi Hidetoshi
Department Of Animal Health School Of Veterinary Medicine Rakuno Gakuen Univeristy
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Yayou Kenichi
National Agricultural Research Center For Hokkaido Region
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NAGAHATA Hajime
Department of Animal Health, School of Veterinary Medicine, Rakuno Gakuen University
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HIGUCHI Hidetoshi
Department of Animal Health, School of Veterinary Medicine, Rakuno Gakuen University
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CHANG Chai
Department of Animal Science, National Chung Hsing University
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KAWAI Hiroatsu
National Agricultural Research Center for Hokkaido Region
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KAWAI Kazuhiro
Department of Animal Health, School of Veterinary Medicine, Azabu University
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