Functional Gene Polymorphisms of Interleukin-10 are Associated with Liver Disease Progression in Japanese Patients with Hepatitis C Virus Infection
スポンサーリンク
概要
- 論文の詳細を見る
Objective The inter-individual difference in response to liver injury appears to be important in the progression of liver fibrosis. Interleukin 10 (IL-10) is an anti-inflammatory cytokine, and several functional gene polymorphisms have been found. The aim of this study was to examine the possible association of IL-10 polymorphisms with the progression of liver fibrosis in hepatitis C virus (HCV)-related chronic liver disease patients. Methods We examined the IL-10 -1087 A/G and -824 T/C gene polymorphisms in 184 Japanese patients with HCV-related chronic liver disease: 94 chronic hepatitis (CH) and 90 with liver cirrhosis (LC). Results There were no significant differences in the genotype distributions or allele frequencies of IL-10 -824 T/C and -1087 A/G between the CH and LC groups. However, among the cirrhotic patients, the lower transcriptional allele, -824 T homozygotes had significantly lower serum albumin and platelet counts, and a higher Child-Pugh score than the -824 C carriers, and the lower transcriptional allele, -1087 A homozygotes had a higher ICG-R 15 compared with -1087 G carriers. Haplotype analysis of IL-10 -1087/-824 showed no significant difference between the CH and LC groups, but the combinations of AT and AC haplotypes (AT/AT, AT/AC and AC/AC) had a significantly higher ICG-R 15 than the GC carriers. Conclusion IL-10 lower transcriptional -824 T allele, -1087 A allele, and -1087/-824 haplotypes AT and AC are risk factors for the progression of liver fibrosis in HCV-related chronic liver disease.
著者
-
Murawaki Yoshikazu
Division Of Medicine And Clinical Science Department Of Multidisciplinary Internal Medicine Faculty
-
Ikebuchi Yuichiro
Division Of Medicine And Clinical Science Faculty Of Medicine Tottori University
-
Ishida Chihiro
Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, Tottori University School of Medicine, Japan
-
Okamoto Kinya
Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, Tottori University School of Medicine, Japan
-
Ikebuchi Yuichiro
Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, Tottori University School of Medicine, Japan
関連論文
- Preventive effects of ME3738 on hepatic fibrosis induced by bile duct ligation in rats
- Functional Gene Polymorphisms of Interleukin-10 are Associated with Liver Disease Progression in Japanese Patients with Hepatitis C Virus Infection
- Idiopathic intrahepatic arterioportal fistula treated by hepatectomy assisted by balloon-occluded retrograde transvenous obliteration : Report of an elderly case
- The impact of visceral fat in nonalcoholic fatty liver disease : cross-sectional and longitudinal studies
- The prevalence of atherosclerosis in cirrhotic patients : assessment of two aspects of atherosis and sclerosis
- The influence on liver parenchymal function and complications of radiofrequency ablation or the combination with transcatheter arterial embolization for hepatocellular carcinoma
- Comparison of clinical laboratory liver tests between asymptomatic HBV and HCV carriers with persistently normal aminotransferase serum levels
- Diagnostic value of serum markers of connective tissue turnover for predicting histological staging and grading in patients with chronic hepatitis C
- Post-Prandial Serum Hyaluronan Concentration in Patients with Chronic Liver Disease
- Influence of a history of gastrectomy for gastric cancer on serum hyaluronan concentration in normal individuals and patients with chronic liver disease
- Effects of Bathing in Hot Water on Portal Hemodynamics in Healthy Subjects and in Patients with Compensated Liver Cirrhosis
- Ultrasonographic findings in isolated superior mesenteric artery dissection
- Contrast-enhanced ultrasonography revealed active thoracic bleeding
- Hepatocellular carcinoma with sarcomatous change arising after radiofrequency ablation for well-differentiated hepatocellular carcinoma
- Rapid Identification of Bacterial Species with Bacterial DNA Microarray in Cirrhotic Patients with Spontaneous Bacterial Peritonitis
- SCHISTOSOMIASIS JAPONICA IDENTIFIED BY LAPAROSCOPIC AND COLONOSCOPIC EXAMINATION
- Prevalence of organic colonic lesions in patients meeting Rome III criteria for diagnosis of IBS : a prospective multi-center study utilizing colonoscopy
- Assessment of Track Microbubble Flow Signals on Contrast-enhanced Ultrasound with Perflubutane Following Percutaneous Liver Biopsy
- Therapeutic effects of ezetimibe for non-alcoholic steatohepatitis in fatty liver shionogi-ob/ob mice
- Nutritional management contributes to improvement in minimal hepatic encephalopathy and quality of life in patients with liver cirrhosis : A preliminary, prospective, open-label study