Canine mdr1 Gene Mutation in Japan
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概要
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Frequency of the 4-bp deletion mutant in canine mdr1 gene was examined in 193 dogs of eight breeds in Japan. The mutant allele was found in Collies, Australian Shepherds, and Shetland Sheepdogs, where its respective frequencies were 58.3%, 33.3%, and 1.2%. The MDR1 protein was detected on peripheral blood mononuclear cells (PBMC) from a MDR1/MDR1 dog, but not on PBMC from a mdr1-1Δ/mdr1-1Δ Collie. Rhodamine 123 was extruded from MDR1/MDR1 lymphocytes. That excretion was inhibited by a MDR1 inhibitor, verapamil. On the other hand, Rh123 excretion was not observed from lymphocytes derived from a mdr1-1Δ/mdr1-1Δ Collie. These results indicated that the mutant mdr1 allele also existed in Collie-breed dogs in Japan at high rates and that mdr1-1Δ /mdr1-1Δ dogs have no functional MDR1.
- 公益社団法人 日本獣医学会の論文
著者
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Iwasaki Toshiroh
Department Of Veterinary Internal Medicine Faculty Of Agriculture Tokyo University Of Agriculture An
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Kawabata Akiko
Department Of Natural Science Osaka Women's University
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Momoi Yasuyuki
Department Of Veterinary Diagnostic Imaging Faculty Of Agriculture Kagoshima University
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IWASAKI Toshiroh
Department of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
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MOMOI Yasuyuki
Department of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
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INOUE-MURAYAMA Miho
Laboratory of Animal Genetics, Department of Agricultural Science, Faculty of Applied Biological Sciences, Gifu University
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KAWABATA Akiko
Department of Veterinary Internal Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
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