Biphasic Tracheal Relaxation Induced by Higenamine and Nantenine From Nandina domestica THUNBERG
スポンサーリンク
概要
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We compared the effects of the extract from fruits of Nandina domestica THUNBERG (NDE) and its constituents, higenamine and nantenine, on contractile responses in isolated guinea-pig trachea. NDE (1 mg/ml) caused biphasic relaxation of the trachea precontracted with high-K+ stimulation: the fast component was blocked by propranolol and mimicked by higenamine; and the slow was resistant to propranolol and mimicked by nantenine. Ca2+-induced contraction under high-K+ stimulation was antagonized by nantenine or NDE + propranolol. These results suggest that NDE relaxes the trachea quickly through β-adrenoceptor stimulation by higenamine and slowly through Ca2+ antagonism by nantenine.
著者
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Ueki Takuro
Laboratory of Pharmacology, Faculty of Pharmacy and Research Institute of Pharmaceutical Sciences, M
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Akaishi Tatsuhiro
Laboratory of Pharmacology, Faculty of Pharmacy and Research Institute of Pharmaceutical Sciences, M
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Okumura Hidenobu
TOKIWA Pharmaceutical Co., Ltd., Japan
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Morioka Tsuneo
TOKIWA Pharmaceutical Co., Ltd., Japan
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Abe Kazuho
Laboratory of Pharmacology, Faculty of Pharmacy and Research Institute of Pharmaceutical Sciences, M
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Abe Kazuho
Laboratory Of Pharmacology Faculty Of Pharmacy And Research Institute Of Pharmaceutical Sciences Mus
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Abe Kazuho
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Science The University Of Toky
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Akaishi Tatsuhiro
Laboratory Of Pharmacology Faculty Of Pharmacy And Research Institute Of Pharmaceutical Sciences Mus
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Okumura Hidenobu
Tokiwa Pharmaceutical Co. Ltd.
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Ueki Takuro
Laboratory Of Pharmacology Faculty Of Pharmacy And Research Institute Of Pharmaceutical Sciences Mus
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Morioka Tsuneo
Tokiwa Pharmaceutical Co. Ltd.
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