Lipopolysaccharide-Induced Suppression of the Hypothalamic Gonadotropin-Releasing Hormone Pulse Generator in Ovariectomized Goats
スポンサーリンク
概要
- 論文の詳細を見る
Ovariectomized goats were implanted with the electrode arrays for monitoring the electrophysiological manifestation of the activity of the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator, namely multiple-unit activity (MUA) volleys associated with pulsatile luteinizing hormone secretion. They were then subjected to i.v. challenges of lipopolysaccharide (LPS) at the dose of 200 or 400 ng/kg. The interval between the MUA volleys was significantly prolonged by higher dose of LPS whereas neither amplitude nor duration of the MUA volleys was altered. These results suggest that immunological disturbance as evoked by LPS administration directly affects the hypothalamic GnRH pulse generator by slowing down the pulse frequency, and thereby lowers gonadotropin secretion from the anterior pituitary gland, which would culminate in gonadal suppression.
論文 | ランダム
- 職業生活が中年期夫婦の関係満足度と主観的幸福感に及ぼす影響 : 妻の就業形態別にみたクロスオーバーの検討
- 夫婦のコミュニケーションと関係満足度,心理的健康の関連--子育て期のペア・データの分析
- 多重役割に従事する子育て期夫婦の関係満足度と心理的健康 ─妻の就業形態による比較─
- 夫婦関係満足度にみるジェンダー差の分析--関係は,なぜ維持されるか
- PD079 仕事へのコミットメントが夫婦関係と心理的健康に及ぼす影響 : ペア・データを用いた交差効果、流出効果の分析(ポスター発表D,研究発表)