Diabetes-induced Testicular Disorders Vis-a-vis Germ Cell Apoptosis in Albino Rat: Remedial Effect of Hexane Fraction of Root of Musa paradisiaca and Leaf of Coccinia indica

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概要

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• The present study was designed to investigate diabetes induced germ cell apoptosis in testis and its protection by treatment with hexane fraction of hydro-methanolic extract of root of Musa paradisiaca and leaf of Coccinia indica in composite manner. Testicular oxidative stress injury was reflected by diminution in the activities of antioxidant enzymes such as catalase, peroxidase, superoxide dismutase and glutathione-s-transferase along with elevation in levels of conjugated diene and thiobarbituric acid reactive substances in diabetic condition. Serum testosterone and insulin levels were decreased in association with elevation in apoptosis of pancreatic islet cells in diabetic rats. Giant cells number along with elevation in the number of apoptotic cells were noted in seminiferous tubules in diabetic model animals. Significant improvements in the levels of blood glucose, serum insulin and testosterone and testicular oxidative stress parameters were noted versus control after treatment of said fraction at a dose of 2 mg (1:3)/0.2 ml olive oil per 100 g body weight per day for 45 days to diabetic rats. Numbers of giant cells in seminiferous tubules, apoptotic germ cells and apoptotic pancreatic islet cells were decreased significantly in fraction treated diabetic group versus control. From UV-spectroscopic and TLC studies in connection with phytochemical screening of the said fraction, phenol, flavonoid and alkaloid types of compound were found. From these results it may be concluded that the active ingredient(s) present in hexane fraction of root of Musa paradisiaca and leaf of Coccinia indica have the potential to correct diabetes-induced testicular germ cell apoptosis.

著者

• Mallick Chhanda

  Reproductive Endocrinology & Molecular Medicine Unit, Dept. of Bio-Medical Laboratory Science and Ma

• Bera Tushar

  Reproductive Endocrinology & Molecular Medicine Unit, Dept. of Bio-Medical Laboratory Science and Ma

• Ali Kazi

  Reproductive Endocrinology & Molecular Medicine Unit, Dept. of Bio-Medical Laboratory Science and Ma

• Chatterjee Kausik

  Reproductive Endocrinology & Molecular Medicine Unit, Dept. of Bio-Medical Laboratory Science and Ma

• Ghosh Debidas

  Reproductive Endocrinology & Molecular Medicine Unit, Dept. of Bio-Medical Laboratory Science and Ma

• Ali Kaz

  Reproductive Endocrinology & Molecular Medicine Unit, Dept. of Bio-Medical Laboratory Science and Ma

• Ali Kazi

  Reproductive Endocrinology & Molecular Medicine Unit, Dept. of Bio-Medical Laboratory Science and Management (U.G.C. Innovative Funded Department), Vidyasagar University

• Mallick Chhanda

  Reproductive Endocrinology & Molecular Medicine Unit, Dept. of Bio-Medical Laboratory Science and Management (U.G.C. Innovative Funded Department), Vidyasagar University

• Bera Tushar

  Reproductive Endocrinology & Molecular Medicine Unit, Dept. of Bio-Medical Laboratory Science and Management (U.G.C. Innovative Funded Department), Vidyasagar University

関連論文

• Diabetes-induced Testicular Disorders Vis-a-vis Germ Cell Apoptosis in Albino Rat: Remedial Effect of Hexane Fraction of Root of Musa paradisiaca and Leaf of Coccinia indica
• Diabetes-induced testicular disorders vis-a vis germ cell apoptosis in albino rat: remedial effect of hexane fraction of root of Musa paradisiaca and leaf of Coccinia indica
• Protection of Testicular Dysfunctions by MTEC, a Formulated Herbal Drug, in Streptozotocin Induced Diabetic Rat(Pharmacology)
• Attenuation of Hyperglycemia and Hyperlipidemia in Streptozotocin-Induced Diabetic Rats by Aqueous Extract of Seed of Tamarindus indica(Pharmacology)

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