Attenuation of Hyperglycemia and Hyperlipidemia in Streptozotocin-Induced Diabetic Rats by Aqueous Extract of Seed of Tamarindus indica(Pharmacology)
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概要
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Streptozotocin (STZ)-induced diabetic rats were divided into mild diabetic (MD) and severe diabetic (SD) on the basis of fasting blood glucose (FBG) levels. Diabetes was confirmed here by intravenous glucose tolerance test (GTT), biochemical assay of glycogen content in liver and skeletal muscle, glucose-6-phosphatase activity in liver, and serum insulin levels. Hyperlipidemia developed in these experimental diabetic rats was assessed by quantification of total cholesterol (TC), high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc) and triglyceride (TG) in serum. Aqueous extract of seed of Tamarindus indica was given to MD and SD rats at the dose of 80mg and 120mg/0.5ml distilled water/100g body weight/d respectively for 14d. Significant attenuation of hyperglycemia was indicated by measuring FBG, glycogen level and glucose-6-phosphatase activity along with monitoring of intravenous GTT and serum insulin level. Similarly, correction of hyperlipidemia in diabetic rats after this extract supplementation was confirmed by significant reduction in the levels of above-mentioned hyperlipidemic indicators. Intravenous GTT was performed that highlights the antidiabetic action of this extract is not due to its effect on the intestinal rate of glucose absorption but may be due to modulation of intracellular glucose utilization in target organs. This study focus the efficacy of this extract for the management of experimental diabetes in rat model which may shed some light on the scientific basis of ancient herbal therapy in this line using this seed.
- 公益社団法人日本薬学会の論文
- 2005-07-01
著者
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Ghosh Debidas
Reproductive Endocrinology & Molecular Medicine Unit, Dept. of Bio-Medical Laboratory Science and Ma
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Ghosh Debidas
Reproductive Endocrinology And Family Welfare Research Unit Department Of Human Physiology With Comm
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MAITI Rajkumar
Reproductive Endocrinology and Family Welfare Research Unit, Department of Human Physiology with Com
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DAS Uttam
Reproductive Endocrinology and Family Welfare Research Unit, Department of Human Physiology with Com
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Das Uttam
Reproductive Endocrinology And Family Welfare Research Unit Department Of Human Physiology With Comm
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Maiti Rajkumar
Reproductive Endocrinology And Family Welfare Research Unit Department Of Human Physiology With Comm
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- Diabetes-induced testicular disorders vis-a vis germ cell apoptosis in albino rat: remedial effect of hexane fraction of root of Musa paradisiaca and leaf of Coccinia indica
- Attenuation of Hyperglycemia and Hyperlipidemia in Streptozotocin-Induced Diabetic Rats by Aqueous Extract of Seed of Tamarindus indica(Pharmacology)