Construction of a Dominant Negative Form of Human Hypoxia-Inducible Factor-2α

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概要

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• We constructed a dominant negative form of human hypoxia-inducible factor (HIF)-2α, HIF-2αDoN, which inhibited HIF transcriptional activity induced by hypoxia and by HIF-2α. HIF-2αDoN formed a complex with HIF-1β and interacted with DNA containing hypoxia response elements (HREs). Thus, the complex appears to inhibit the binding of HIF-2 to HREs, and HIF-2αDoN might provide a useful therapeutic tool for HIF-2α-related diseases.

• 社団法人 日本農芸化学会の論文

著者

• Yamaji Ryoichi

  Division Of Applied Biological Chemistry Graduate School Of Agriculture And Biological Sciences Osak

• Harada Naoki

  Div. Of Applied Life Sciences Graduate School Of Life And Environmental Sciences Osaka Prefecture Un

• Higashimura Yasuki

  Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefect

• Harada Naoki

  Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefect

• NAKAO Motoyuki

  Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefect

• NAKANO Yoshihisa

  Osaka Women’s Junior College

• INUI Hiroshi

  Division of Applied Life Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefect

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