Glycogen Synthase Kinase-3β Inhibition of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi (Wasabia japonica Matsum)

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概要

• 論文の詳細を見る

• A new biological activity of 6-(methylsulfinyl)hexyl isothiocyanate derived from Wasabia japonica was discovered as an inhibitor of glycogen synthase kinase-3β. The most potent isothiocyanate, 9-(methylsulfinyl)hexyl isothiocyanate, inhibited glycogen synthase kinase-3β at a Ki value of 10.5 μM and showed ATP competitive inhibition. The structure-activity relationship revealed an inhibitory potency of methylsulfinyl isothiocyanate dependent on the alkyl chain length and the sulfoxide, sulfone, and/or the isothiocyanate moiety.

著者

• Yoshida Jun

  The United Graduate School of Agricultural Sciences, Iwate University

• Nomura Satomi

  Faculty of Agriculture, Iwate University

• Nishizawa Naoyuki

  The United Graduate School of Agricultural Sciences, Iwate University

• ITO Yoshiaki

  The United Graduate School of Agricultural Sciences, Iwate University

• KIMURA Ken-ichi

  The United Graduate School of Agricultural Sciences, Iwate University

関連論文

• Glycogen Synthase Kinase-3β Inhibition of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi (Wasabia japonica Matsum)
• Content of Free D-Ala and D-Glu in Traditional Asian Fermented Seasonings
• Content of Free D-Ala and D-Glu in Traditional Asian Fermented Seasonings
• Glycogen Synthase Kinase-3β Inhibition of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi (Wasabia japonica Matsum)

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