Glycogen Synthase Kinase-3β Inhibition of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi (Wasabia japonica Matsum)
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概要
- 論文の詳細を見る
A new biological activity of 6-(methylsulfinyl)hexyl isothiocyanate derived from Wasabia japonica was discovered as an inhibitor of glycogen synthase kinase-3β. The most potent isothiocyanate, 9-(methylsulfinyl)hexyl isothiocyanate, inhibited glycogen synthase kinase-3β at a Ki value of 10.5 μM and showed ATP competitive inhibition. The structure-activity relationship revealed an inhibitory potency of methylsulfinyl isothiocyanate dependent on the alkyl chain length and the sulfoxide, sulfone, and/or the isothiocyanate moiety.
- 2011-01-23
著者
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Yoshida Jun
The United Graduate School of Agricultural Sciences, Iwate University
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Nomura Satomi
Faculty of Agriculture, Iwate University
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Nishizawa Naoyuki
The United Graduate School of Agricultural Sciences, Iwate University
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ITO Yoshiaki
The United Graduate School of Agricultural Sciences, Iwate University
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Nishizawa Naoyuki
The United Graduate School Of Agricultural Sciences Iwate Univ.
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Nishizawa Naoyuki
The United Graduate School Of Agricultural Sciences Iwate University
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Kimura Ken-ichi
The United Graduate School Of Agricultural Sciences Iwate University
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Yoshida Jun
The United Graduate School Of Agricultural Sciences Iwate University
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Ito Yoshiaki
The United Graduate School Of Agricultural Sciences Iwate University
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Nomura Satomi
Faculty Of Agriculture Iwate University
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Kimura Ken-ichi
The United Graduate School Of Agricultural Sciences Iwate Univ.
関連論文
- Glycogen Synthase Kinase-3β Inhibition of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi (Wasabia japonica Matsum)
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- Glycogen Synthase Kinase-3β Inhibition of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi (Wasabia japonica Matsum)
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