Synthesis and Antimicrobial Study of Linked Heterocyclics Containing Pyrazole-pyrimidine-thiazolidin-4-one

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概要

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• A new series of linked heterocyclics, 3-[4-(4-chlorophenyl)-6-(3,5-dimethyl-1-phenyl-1H-4-pyrazolyl)-2-pyrimidinyl]-2-(aryl/heteryl)-1,3-thiazolan-4-ones (6a—j), has been synthesized by the one-pot cyclo-condensation of 4-(4-chlorophenyl)-6-(3,5-dimethyl-1-phenyl-1H-4-pyrazolyl)-2-pyrimidinamine (5), aryl/heteroaryl aldehyde and thioglycolic acid. The structures of the synthesized compounds have been confirmed via IR, 1H-NMR, 13C-NMR, MS and elemental analyses. Further, all the newly synthesized compounds 6a—j have been assayed for their antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi. The compounds containing moieties like 4-nitrophenyl (6c), 3-nitrophenyl (6d), 4-dimethylaminophenyl (6g), 2-furyl (6i) and 1,3-benzodioxole (6j), at 2-position of thiazolidin-4-one ring exhibited good inhibitory activity against all the tested organisms.

• 公益社団法人　日本薬学会の論文

著者

• SANJEEVA REDDY

  Department of Chemistry, Kakatiya University

• Nagaraj Adki

  Department of Pharmaceutical Chemistry, Telangana University

• Vani Devi

  Department of Chemistry, Kakatiya University

• Sunitha Malladi

  Department of Chemistry, Kakatiya University

• Nagaraj Adki

  Department of Chemistry, Kakatiya University

関連論文

• Synthesis, Nematicidal and Antimicrobial Properties of Bis-[4-methoxy-3-[3-(4-fluorophenyl)-6-(4-methylphenyl)-2(aryl)-tetrahydro-2H-pyrazolo[3,4-d]thiazol-5-yl]phenyl]methanes
• Synthesis of Novel 6,6'-Methylene-bis-[3-(2-anilinoacetyl)-4-hydroxycoumarin] Derivatives
• Synthesis of New 1,2,4-Triazole[3,4-b][1,3,4]thiadiazoles Bearing Pyrazole as Potent Antimicrobial Agents
• Synthesis, Nematicidal and Antimicrobial Activity of 3-(5-3-Methyl-5-[(3-methyl-7-5-[2-(aryl)-4-oxo-1,3-thiazolan-3-yl]-1,3,4-thiadiazol-2-ylbenzo[b]furan-5-yl)methyl]benzo[b]furan-7-yl-1,3,4-thiadiazol-2-yl)-2-(aryl)-1,3-thiazolan-4-one
• Synthesis and Antimicrobial Study of Linked Heterocyclics Containing Pyrazole-pyrimidine-thiazolidin-4-one

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