Synthesis of Novel 6,6'-Methylene-bis-[3-(2-anilinoacetyl)-4-hydroxycoumarin] Derivatives

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概要

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• The synthesis of novel 6,6'-methylene-bis-[3-(2-anilinoacetyl)-4-hydroxycoumarin] derivatives 6a-f was achieved in excellent yields from 6,6'-methylene-bis-[3-(2-bromoacetyl)-4-hydroxycoumarin] 5 and various arylamines. 5,5'-Methylene-bis-ethylsalicylate 3 was obtained by the esterfication of 5,5'-methylene-bis-salicylic acid 2 with ethanol, which was in turn obtained from salicylic acid 1 and formaldehyde. Cyclocondensation of 3 with ethyl acetoacetate resulted in 6,6'-methylene-bis-[3-acetyl-4-hydroxycoumarin] 4, which on selective α-bromination with molecular bromine in the presence of montmorillonite K10-AlCl_3 catalyst, in chloroform-ethyl acetate binary solvent mixture at room temperature, afforded the compound 5 in excellent yield. All the newly synthesized compounds were characterized by their spectral data.

• 公益社団法人日本薬学会の論文
• 2008-12-01

著者

• Sanjeeva Reddy

  Dep. Of Chemistry Kakatiya Univ.

• SANJEEVA REDDY

  Department of Chemistry, Kakatiya University

• RAGHU Mekala

  Department of Chemistry, Kakatiya University

• Raghu Mekala

  Department Of Chemistry Kakatiya University

関連論文

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• Synthesis of Novel 6,6'-Methylene-bis-[3-(2-anilinoacetyl)-4-hydroxycoumarin] Derivatives
• Synthesis of New 1,2,4-Triazole[3,4-b][1,3,4]thiadiazoles Bearing Pyrazole as Potent Antimicrobial Agents
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• Synthesis and Antimicrobial Study of Linked Heterocyclics Containing Pyrazole-pyrimidine-thiazolidin-4-one

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