Development and Application of a Method to Investigate Drug-Metabolizing Enzyme Inhibitors Using Sparteine for Probe of Cytochrome P450 2D6 and Tris(2,2′-bipyridine)ruthenium(II)-Electrogenerated Chemiluminescence Detection

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概要

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• We studied the detection of drug-metabolizing enzyme inhibitiors using column-switching high performance liquid chromatography with tris(2,2′-bipyridine)ruthenium(II) (Ru(bpy)32+)-electrogenerated chemiluminescence detection. This can be applied to evaluate the genetic diversity concerning the ability of cytochrome P450 (CYP) 2D6 to metabolize drug in vitro. We demonstrated the ability of CYP2D6 to enable us to examine drugs metabolizing enzyme inhibition with high performance and sensitivity. This method can be applied to investigate metabolite inhibitors of CYP2D6 in vitro and in vivo. Thus, Metixene was found to be a potential CYP2D6 inhibitor.

著者

• Shibano Yuu

  College of Pharmacy, Nihon University

• Taki Shiwori

  College of Pharmacy, Nihon University

• Miyamoto Aoi

  College of Pharmacy, Nihon University

• Uchikura Kazuo

  College of Pharmacy, Nihon University

• Uchikura Kazuo

  College Of Pharmacy Nihon University

関連論文

• Development and Application of a Method to Investigate Drug-Metabolizing Enzyme Inhibitors Using Sparteine for Probe of Cytochrome P450 2D6 and Tris(2,2′-bipyridine)ruthenium(II)-Electrogenerated Chemiluminescence Detection
• Tris (2, 2'-bipyridine)ruthenium(III)Chemiluminescence Detection of Carbonyl Compounds with Methylmalonic Acid
• Ru(bpy)_3^ Electrochemiluminescence Detection of Aliphatic and Aromatic Amines with Diketene
• Electochemiluminescence Reaction by Mixing Tris(2, 2'-bipyridine)-ruthenium(III)with Ketones
• Determination of Aromatic and Branched-Chain Amino Acids in Plasma by HPLC with Electrogenerated Ru (bpy)^_3 Chemiluminescence Detection
• Direct enantiomeric separation of β-aminoalcohols with a tertiary amine moiety by ligand-exchange chromatography with chemiluminescence detection

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