Effects of an Oleaginous Calcitriol on Changes in Plasma Calcitriol, Calcium and Bone Metabolic Markers in Dairy Cows
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概要
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The present study evaluated the effects of calcitriol dissolved in an oleaginous vehicle (calcitriol-OLE) on changes in plasma calcitriol, calcium and bone metabolic markers in nonpregnant, nonlactating Holstein cows. Five cows were treated intramuscularly or subcutaneously with calcitriol-OLE and oleaginous vehicle alone using a 5 × 5 Latin square design. Additionally, cows were also treated intravenously with calcitriol dissolved in aqueous vehicles (calcitriol-AQU) for comparison. Plasma calcitriol concentrations after intramuscular and subcutaneous calcitriol-OLE administrations peaked at 24 and 12 hr, respectively, remained significantly elevated until day 3, returned to the respective control levels on day 5 and decreased significantly on day 7. In cows given intravenous calcitriol-AQU, calcitriol levels decreased with linearity on day 1. Plasma calcium levels rose from 12 hr post-dose, and peaked on day 2 for both preparations and in all three administration routes. Significantly increased calcium levels continued until day 5 in intramuscular and intravenous routes and day 7 in subcutaneous route. Plasma osteocalcin concentrations significantly increased from day 3 for calcitriol-OLE and from day 5 for calcitriol-AQU, whereas the bone resorption markers, tartrate-resistant acid phosphatase and hydroxyproline, decreased during this time. These results suggest that either intramuscular or subcutaneous injection of calcitriol-OLE extends and maintains supraphysiological calcitriol levels in the plasma and prolongs hypercalcemia. Moreover, exogenous calcitriol to normocalcemic cows increases the plasma osteocalcin concentration, and decreases the plasma level of bone resorption markers probably due to hypercalcemia.
著者
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Kim Danil
United Graduate School of Veterinary Sciences, Gifu University
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Furuhama Kazuhisa
United Graduate School Of Veterinary Sci. Gifu Univ.
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YAMAGISHI Norio
United Graduate School of Veterinary Science, Gifu University
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ABE Izumi
Nippon Zenyaku Kogyo Co., Ltd.
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OHASHI Shuichi
Nippon Zenyaku Kogyo Co., Ltd., Fukushima 963-0196, Japan
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DEVKOTA Bhuminand
Department of Clinical Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University
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DEVKOTA Bhuminand
Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
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OHASHI Shuichi
Nippon Zenyaku Kogyo Co., Ltd.
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