Synthesis, Crystal Structure, Antioxidant Activity, and DNA-Binding Studies of a Novel Ni(II) [2×2] Grid Complex with a Rigid Bistridentate Schiff Base Ligand
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概要
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With a bistridentate Schiff-base ligand, N′,N′3-bis[(1E)-1-(2-pyridinyl)ethylidene)] isophthalohydrazide (H2L), a [2×2]G grid complex, [Ni4(HL)4](ClO4)4·4H2O·0.5 CH3OH (1) has been synthesized and characterized spectroscopically and crystallographically. Spectrometric titrations, ethidium bromide displacement experiments, circular dichroism spectral analysis and viscosity measurements indicate that the compound 1 strongly binds with calf-thymus DNA, presumably via intercalation mechanism. Furthermore, the antioxidant activity (superoxide and hydroxyl radical) of the ligand and its nickel(II) complex is determined by using spectrophotometer methods in vitro. Complex 1 is found to possess potent antioxidant activity and be better than standard antioxidants like mannitol.
- 社団法人 日本薬学会の論文
著者
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Cheng Fei-xiang
Key Lab. Of Nonferrous Metal Chemistry And Resources Utilization Of Gansu Province State Key Lab. Of
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Jia Lei
Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key
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Xu Jun
Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key
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Xu Xi-Ming
School of Life Science, Lanzhou University
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Chen Long-Hai
Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key
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Jiang Peng
School of Life Science, Lanzhou University
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Lu Guang-Nong
Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key
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Wang Qin
School of Life Science, Lanzhou University
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Wu Jin-Cai
Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key
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Tang Ning
Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key
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Xu Xi-ming
Dep. Of Pharmaceutics School Of Pharmacy Jiangsu Univ.
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Cheng Fei-Xiang
Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University
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Lu Guang-Nong
Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University
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Tang Ning
Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University
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Wu Jin-Cai
Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University
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Jia Lei
Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University
関連論文
- Synthesis, Crystal Structure, Antioxidant Activity, and DNA-Binding Studies of a Novel Ni(II) [2×2] Grid Complex with a Rigid Bistridentate Schiff Base Ligand
- Synthesis, Characterization, Cytotoxic Activities, and DNA-Binding Studies of Ternary Copper(II) Complexes with New Coumarin Derivatives