Synthesis, Characterization, Cytotoxic Activities, and DNA-Binding Studies of Ternary Copper(II) Complexes with New Coumarin Derivatives

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概要

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• In this study, two novel complexes [Cu(MCVH)phen(H2O)]·ClO4 (1) and [Cu(MCLH)phen(H2O)]·ClO4 (2) (here, MCVH2=(7-hydroxy-4-methyl-8-coumarinyl) valine, MCLH2=(7-hydroxy-4-methyl-8-coumarinyl) leucine) have been synthesized and characterized by elemental analyses, molar conductance, infrared spectra (IR), 1H-NMR and UV–Vis measurements. The interactions of them with calf thymus DNA (ct DNA) have been investigated by absorption spectroscopy, fluorescence spectroscopy, circular dichroism spectroscopy and viscosity measurements. Experimental results reveal an intercalative interaction with DNA for the complexes, furthermore the binding affinity of 2 is higher than that of 1 according to the calculated binding constant values. In addition, they were evaluated for their cytotoxic activities toward human prostate cancer cell (PC3), human liver cell (L02) and human myeloid leukemia cancer cell (HL-60) by acid phosphoatase assay. Both of them showed significant cytotoxic potency.

• 社団法人 日本薬学会の論文

著者

• Cheng Fei-xiang

  Key Lab. Of Nonferrous Metal Chemistry And Resources Utilization Of Gansu Province State Key Lab. Of

• Jia Lei

  Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key

• Xu Jun

  Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key

• Xu Xi-Ming

  School of Life Science, Lanzhou University

• Chen Long-Hai

  Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key

• Jiang Peng

  School of Life Science, Lanzhou University

• Lu Guang-Nong

  Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key

• Wang Qin

  School of Life Science, Lanzhou University

• Wu Jin-Cai

  Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key

• Tang Ning

  Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key

• Xu Xi-ming

  Dep. Of Pharmaceutics School Of Pharmacy Jiangsu Univ.

関連論文

• Synthesis, Crystal Structure, Antioxidant Activity, and DNA-Binding Studies of a Novel Ni(II) [2×2] Grid Complex with a Rigid Bistridentate Schiff Base Ligand
• Synthesis, Characterization, Cytotoxic Activities, and DNA-Binding Studies of Ternary Copper(II) Complexes with New Coumarin Derivatives

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