Relation between the Estimated Glomerular Filtration Rate and Pulse Wave Velocity in Japanese
スポンサーリンク
概要
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Objective We investigated the link between renal function as evaluated by estimated glomerular filtration rate (eGFR) and pulse wave velocity (PWV) in Japanese without medications. Methods A total of 1,244 Japanese subjects, aged 20-79 years, were recruited in a cross-sectional clinical investigation study. They received no medications. eGFR was calculated using serum creatinine (Cr), age and sex. Peripheral arterial stiffness was evaluated by brachial-ankle PWV (baPWV). Results eGFR and baPWV were significantly correlated with age. eGFR was negatively correlated with baPWV (men: r=-0.308, p<0.0001, women: r=-0.293, p<0.0001). Twenty-six men (5.6%) and 35 women (4.5%) were diagnosed as reduced eGFR (eGFR <60 mL/min/1.73 m2). We compared clinical parameters between subjects with reduced eGFR (Group R) and without such reduction (Group N). baPWV in Group R was significantly higher than that in Group N even after adjusting for age. In women, systolic blood pressure in Group R was also significantly higher than that in Group N. Conclusion eGFR was closely associated with peripheral arterial stiffness in Japanese.
著者
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Shikata Kenichi
Department Of Medicine And Clinical Science (internal Medicine Iii) Okayama University Graduate Scho
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Makino Hirofumi
Department Of Clinical Gene Therapy Osaka University Graduate School Of Medicine
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NUMATA Takeyuki
Okayama Southern Institute of Health
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Miyatake Nobuyuki
Department Of Hygiene Faculty Of Medicine Kagawa University
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SHIKATA Kenichi
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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