Hemophagocytic Syndrome Associated with Fatal Veno-Occlusive Disease in the Liver
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概要
- 論文の詳細を見る
A 47-year-old man presented with hemophagocytic syndrome (HPS) without any obvious underlying diseases. On computed tomography, his liver was occupied by multiple ill-defined low intensity lesions. Liver biopsy revealed diffuse infiltration of numerous histiocytes without cytologic atypism and prominent fibrotic changes. These histiocyes showed S100(+), CD68(+), CD1a(-), and lysozyme(+) and Langerhans cell granules were not observed by electron microscopic examination. He failed to respond to immunosuppressive and chemotherapeutic treatments and progressed to severe liver failure. At autopsy, his liver exhibited veno-occulusive disease (VOD). Since VOD is regarded as a rare complication of HPS, the presence of VOD associated with HPS may be easily overlooked.
- 社団法人 日本内科学会の論文
著者
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Makino Hirofumi
Department Of Clinical Gene Therapy Osaka University Graduate School Of Medicine
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Wada Jun
Department Of Medicine And Clinical Science Okayama University Graduate School Of Medicine
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Takeda Masaya
Department Of Medicine And Clinical Science Okayama University Graduate School Of Medicine Dentistry
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Nagase Ryo
Department Of Medicine And Clinical Science Okayama University Graduate School Of Medicine Dentistry
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Yoshino Tadashi
Department Of Cytopathology Ayabe City Hospital
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Nakatsuka Atsuko
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
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Takeda Masaya
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine
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Yoshino Tadashi
Department of Chemical Engineering, Hiroshima University
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Nakatsuka Atsuko
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine
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Nagase Ryo
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine
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