The Synergy of 6-O-Sulfation and N- or 3-O-Sulfation of Chitosan Is Required for Efficient Inhibition of P-Selectin-Mediated Human Melanoma A375 Cell Adhesion

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概要

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• We prepared chitosan sulfated derivatives to address the common structural requirement of the sulfate pattern to block P-selectin-mediated tumor cell adhesion. Our results indicate that 6-O-sulfation of chitosan is indispensable for inhibition of P-selectin binding to human melanoma A375 cells. Furthermore, additional N-sulfation or 3-O-sulfation dramatically enhanced the inhibitory activity of 6-O-sulfated chitosan, suggesting that efficient anti-P-selectin adhesion activity of sulfated saccharides requires the synergy of 6-O-sulation and N- or 3-O-sulfation in glucosamine units.

• 社団法人 日本農芸化学会の論文

著者

• Wang Ruifei

  Institute of Genetics and Cytology, School of Life Sciences, Northeast Normal University

• Huang Jinfeng

  Institute of Genetics and Cytology, School of Life Sciences, Northeast Normal University

• Wei Min

  Institute of Genetics and Cytology, School of Life Sciences, Northeast Normal University

• ZENG Xianlu

  Institute of Genetics and Cytology, School of Life Sciences, Northeast Normal University

関連論文

• The Synergy of 6-O-Sulfation and N- or 3-O-Sulfation of Chitosan Is Required for Efficient Inhibition of P-Selectin-Mediated Human Melanoma A375 Cell Adhesion
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• The Synergy of 6-O-Sulfation and N- or 3-O-Sulfation of Chitosan Is Required for Efficient Inhibition of P-Selectin-Mediated Human Melanoma A375 Cell Adhesion

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