The Synergy of 6-O-Sulfation and N- or 3-O-Sulfation of Chitosan Is Required for Efficient Inhibition of P-Selectin-Mediated Human Melanoma A375 Cell Adhesion

スポンサーリンク

概要

• 論文の詳細を見る

• We prepared chitosan sulfated derivatives to address the common structural requirement of the sulfate pattern to block P-selectin-mediated tumor cell adhesion. Our results indicate that 6-O-sulfation of chitosan is indispensable for inhibition of P-selectin binding to human melanoma A375 cells. Furthermore, additional N-sulfation or 3-O-sulfation dramatically enhanced the inhibitory activity of 6-O-sulfated chitosan, suggesting that efficient anti-P-selectin adhesion activity of sulfated saccharides requires the synergy of 6-O-sulation and N- or 3-O-sulfation in glucosamine units.

• 社団法人 日本農芸化学会の論文
• 2010-08-23

著者

• Wang Ruifei

  Institute of Genetics and Cytology, School of Life Sciences, Northeast Normal University

• Huang Jinfeng

  Institute of Genetics and Cytology, School of Life Sciences, Northeast Normal University

• Wei Min

  Institute of Genetics and Cytology, School of Life Sciences, Northeast Normal University

• ZENG Xianlu

  Institute of Genetics and Cytology, School of Life Sciences, Northeast Normal University

• Wei Min

  Institute Of Genetics And Cytology School Of Life Science Northeast Normal University

• Zeng Xianlu

  Institute Of Genetics And Cytology Northeast Normal University

• Huang Jinfeng

  Institute Of Genetics And Cytology School Of Life Sciences Northeast Normal University

• Wei Min

  Institute Of Genetics And Cytology School Of Life Sciences Northeast Normal University

• Wang Ruifei

  Institute Of Genetics And Cytology School Of Life Sciences Northeast Normal University

• Zeng Xianlu

  Institute Of Genetics And Cytology School Of Life Sciences Northeast Normal University

関連論文

• The Synergy of 6-O-Sulfation and N- or 3-O-Sulfation of Chitosan Is Required for Efficient Inhibition of P-Selectin-Mediated Human Melanoma A375 Cell Adhesion
• BAF53 Interacts with p53 and Functions in p53-mediated p21-gene Transcription
• c-Abl Tyrosine Kinase Activates p21 Transcription Via Interaction with p53
• Platelets and fibrinogen facilitate each other in protecting tumor cells from natural killer cytotoxicity
• The Synergy of 6-O-Sulfation and N- or 3-O-Sulfation of Chitosan Is Required for Efficient Inhibition of P-Selectin-Mediated Human Melanoma A375 Cell Adhesion
• c-Abl Is Involved in the F-Actin Assembly Triggered by L-Selectin Crosslinking

スポンサーリンク