Asymmetric hydrogenation of ketones: Tactics to achieve high reactivity, enantioselectivity, and wide scope

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概要

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• Ru complexes with chiral diphosphines and amine-based ligands achieve high catalytic activity and enantioselectivity for the hydrogenation of ketones under neutral to slightly basic conditions. The chiral environment is controllable by changing the combination of these two ligands. A concerted six-membered transition state is proposed to be the origin of the high reactivity. The η6-arene/TsDPEN–Ru and MsDPEN–Cp*Ir catalysts effect the asymmetric reaction under slightly acidic conditions. A variety of chiral secondary alcohols are obtained in high enantiomeric excess.(Communicated by Ryoji NOYORI, M.J.A.)

著者

• Ohkuma Takeshi

  Division Of Chemical Process Engineering Graduate School Of Engineering Hokkaido University

• OHKUMA Takeshi

  Division of Chemical Process Engineering, Graduate School of Engineering, Hokkaido University

関連論文

• Asymmetric hydrogenation of ketones: Tactics to achieve high reactivity, enantioselectivity, and wide scope
• Tailor-made Catalysts for Asymmetric Hydrogenation of Ketones

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