裁判化学におけるCapillary GC/MSの薬物同定への応用I: ヘロインを摂取したヒト尿からの6-アセチルモルヒネの直接検出

概要

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It has been considered that heroin and its metabolites in human urine play a main evidence in most cases of heroin use. However heroin is quickly metabolized and run out from a body. There are a few reports and data on their detective research from human urine samples, but very few about underivatized methods. This study was aimed at examining whether heroin metabolites like as 6-acetylmorphine and morphine could be detected from urine samples by GC/MS without derivatization. Heroin and its metabolites in the human urine sample was directly extracted with chloroform-isopropanol (3:1, pH↔9.5, 20°C) and the extracts were analyzed by GC/MS. In the results, we found some heroin metabolites like 6-acetylmorphine and morphine in the urine sample of a drug addict.The above data suggest that our direct method is useful for evaluating whether a person use heroin or not. It may also be possible to detect metabolites of heroin from urine samples of heroin abusers, if urine samples were quickly taken from the bodys (at least 4 or 5 hours after use of heroin).
日本質量分析学会の論文