質量分析の科学捜査への応用 : モルヒネが検出された尿からの摂取薬物の特定

概要

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After opium ingestion, it is possible to obtain the same analytical results with regard to the presence of morphine in the urine sample as after abuse of diacetylmorphine (heroin). Therefore, it is difficult to determine the abused drug only from the fact of morphine presence in the urine sample. This study was aimed at examining whether the abused drug could be determined from urine samples by detection of morphine and its analogs. Morphine and its analogs in the human urine samples were directly extracted and the extracts were analyzed by capillary GC and identified mass spectrometrically by full mass spectra. In the results, the urine samples were classified into 3 groups: 1) heroin with 6-acetylmorphine or 6-acetylmorphine, 2) thebaine with desmethylpapaverine or desmethylpapaverine, 3) others.The above data suggest that our method is capable of detecting morphine and its analogs in the urine samples, and giving useful informations for determination of the abused drugs.
日本質量分析学会の論文
1996-10-01