Modified Solvent System for Reversed-Phase Liquid Chromatography/Mass Spectrometry

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概要

• 論文の詳細を見る

• Liquid chromatographic influence on changing the solvent system from the non-volatile buffer containing inorganic salts or phosphates to some volatile buffers suitable for the direct coupled liquid chromatography/mass spectrometry was investigated by means of the reversed-phase high-performance liquid chromatography. On a separation of ten methylxanthines including methyluric acids, almost the same chromatograms of the mixture were obtained among all buffers examined. Similar modifications on the solvent system were tried to separate a mixture of nine non-steroidal anti-inflammatory drugs and anthranilic acid. In an application of the modified buffer to the FRIT-FAB liquid chromatography/mass spectrometry, informative negative ion mass spectra of acetyl-coenzyme A and structurally related compounds could be obtained by using diethanolamine-acetic acid buffer. Diethanolamine, its acetate in the buffer, acts effectively as a matrix for the FRIT-FAB liquid chromatography/mass spectrometry.

• 日本質量分析学会の論文

著者

• MOMOSE Atsushi

  Laboratory of Racing Chemistry

• Kamei Katsutoshi

  Laboratory of Racing Chemistry

• Kitahara Kanako

  Laboratory of Racing Chemistry

• Matsuura Kenji

  JEOL LTD

• Yuki Hidetaka

  Faculty of Pharmaceutical Science, Toho University

関連論文

• Theoretical Relationship between the Post-administration Time and Plasma or Urinary Concentration of a Metabolite and the Unchanged Drug. Administration of Caffeine to Horses
• Modified Solvent System for Reversed-Phase Liquid Chromatography/Mass Spectrometry
• NMR spectroscopic studies on the tautomerism in Schiff bases of tenuazonic acid analogs.

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