Antimicrobial and Antileishmanial Studies of Novel (2E)-3-(2-Chloro-6-methyl/methoxyquinolin-3-yl)-1-(Aryl)prop-2-en-1-ones
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概要
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Thirty eight heterocyclic chalcones were synthesized by condensing formylquinolines with diverse methyl arylketones. The target compounds were characterized by spectroscopic techniques (NMR, IR, MS) and elemental analysis. The X-ray crystallographic study of (2E)-3-(2-chloro-6-methylquinolin-3-yl)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-en-1-one (1p) was also performed for the structure confirmation. The title compounds were screened for anti-microbial and antileishmanial activities. The compounds 1c—e, 1g, 1j—m, 1p, 1r—s, 2g, 2j—p, and 2r—s were found potentially active antileishmanial agents, while 1f—i, 1l, 1o—p, 2f—i, 2l, and 2o—p showed remarkable antibacterial activity. Only compounds 1g and 2g—h exhibited significant antifungal activity.
著者
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Rizvi Syed
Institute of Chemistry, University of the Punjab
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Siddiqui Hamid
Institute of Chemistry, University of the Punjab
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Parvez Masood
Department of Chemistry, The University of Calgary
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Ahmad Matloob
Institute of Chemistry, University of the Punjab
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Siddiqui Waseeq
Department of Chemistry, Ibn-e-Sina Block, University of Sargodha
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Yasinzai Muhammad
Institute of Biochemistry, Balochistan University
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Siddiqui Hamid
Institute Of Chemistry University Of The Punjab
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Yasinzai Muhammad
Institute Of Biochemistry University Of Balochistan
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Parvez Masood
Department Of Chemistry Faculty Of Science University Of Calgary
関連論文
- Antimicrobial and Antileishmanial Studies of Novel (2E)-3-(2-Chloro-6-methyl/methoxyquinolin-3-yl)-1-(Aryl)prop-2-en-1-ones
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