Antimicrobial and Antileishmanial Studies of Novel (2E)-3-(2-Chloro-6-methyl/methoxyquinolin-3-yl)-1-(Aryl)prop-2-en-1-ones

スポンサーリンク

概要

• 論文の詳細を見る

• Thirty eight heterocyclic chalcones were synthesized by condensing formylquinolines with diverse methyl arylketones. The target compounds were characterized by spectroscopic techniques (NMR, IR, MS) and elemental analysis. The X-ray crystallographic study of (2E)-3-(2-chloro-6-methylquinolin-3-yl)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-en-1-one (1p) was also performed for the structure confirmation. The title compounds were screened for anti-microbial and antileishmanial activities. The compounds 1c—e, 1g, 1j—m, 1p, 1r—s, 2g, 2j—p, and 2r—s were found potentially active antileishmanial agents, while 1f—i, 1l, 1o—p, 2f—i, 2l, and 2o—p showed remarkable antibacterial activity. Only compounds 1g and 2g—h exhibited significant antifungal activity.

著者

• Rizvi Syed

  Institute of Chemistry, University of the Punjab

• Siddiqui Hamid

  Institute of Chemistry, University of the Punjab

• Parvez Masood

  Department of Chemistry, The University of Calgary

• Ahmad Matloob

  Institute of Chemistry, University of the Punjab

• Siddiqui Waseeq

  Department of Chemistry, Ibn-e-Sina Block, University of Sargodha

• Yasinzai Muhammad

  Institute of Biochemistry, Balochistan University

• Siddiqui Hamid

  Institute Of Chemistry University Of The Punjab

• Yasinzai Muhammad

  Institute Of Biochemistry University Of Balochistan

• Parvez Masood

  Department Of Chemistry Faculty Of Science University Of Calgary

関連論文

• Antimicrobial and Antileishmanial Studies of Novel (2E)-3-(2-Chloro-6-methyl/methoxyquinolin-3-yl)-1-(Aryl)prop-2-en-1-ones
• Synthesis and Antibacterial Activity of Bis[2-amino-4-phenyl-5-thiazolyl] Disulfides
• Synthesis of Potential Biologically Active 1,2-Benzothiazin-3-yl-quinazolin-4(3H)-ones
• New Steroidal Alkaloids from Fritillaria imperialis and Their Cholinesterase Inhibiting Activities
• Latent Activity of Curcumin against Leishmaniasis in Vitro
• Guaianolides from Salvia nubicola (Lamiaceae)
• Synthesis, Characterization and Hypoglycemic Activity of Zn(II), Cd(II) and Hg(II) Complexes with Glibenclamide
• Synthesis, Spectroscopic and Cytotoxic Studies of Biologically Active New Schiff Bases Derived from p-Nitrobenzaldehyde

スポンサーリンク