Preparation, Optimization and Characteristic of Huperzine A Loaded Nanostructured Lipid Carriers
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概要
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The objective of the present work was to study the preparation, optimization and characteristics of Huperzine A (Hup A), an effective Traditional Chinese Medicine treatment of Alzheimers disease (AD), loaded nanostructured lipid carriers (NLC). NLC were successfully prepared by a modified method of melt ultrasonication followed by high pressure homogenization using Cetyl Palmitate (CP) as the solid lipid, Miglyol®812 as the liquid lipid, Soybean phosphatidylcholine (Spc) and Solutol HS15® as the emulsifiers. The best formulation was optimized with a three-factor, three-level Box–Behnken design. Independent variables studied were the amount of the mixed lipid, the amount of the emulsifier mixture and lipid/drug ratio in the formulation. The dependent variables were the particle size, entrapment efficiency (EE) and drug loading (DL). Properties of NLC such as the morphology, particle size, zeta potential, EE, DL and drug release behavior were investigated, respectively. As a result, the designed nanoparticles showed nearly spherical particles with a mean particle size of 120 nm and −22.93±0.91 mV. The EE (%) and DL (%) could reach up to 89.18±0.28% and 1.46±0.05%, respectively. Differential scanning calorimetry (DSC) of Hup A loaded NLC indicated no tendency of recrystallisation. In vitro release studies showed a burst release at the initial stage and followed by a prolonged release of Hup A from NLC up to 96 h. The results suggest that the presented Hup A loaded NLC system is a potential delivery system for improving drug loading capacity and controlled drug release.
著者
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Yang Chun-Rong
School of Pharmacy, Shenyang Pharmaceutical University
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Zhao Xiu-Li
School of Pharmacy, Shenyang Pharmaceutical University
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Hu Hai-Yang
School of Pharmacy, Shenyang Pharmaceutical University
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Li Ke-Xin
School of Pharmacy, Shenyang Pharmaceutical University
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Sun Xin
College Pharmacy of Jiamusi University
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Li Lei
School of Pharmacy, Shenyang Pharmaceutical University
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Chen Da-Wei
School of Pharmacy, Shenyang Pharmaceutical University
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Li Ke-xin
School Of Pharmacy 42 Mailbox Shenyang Pharmaceutical University
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Chen Da-wei
School Of Pharmacy 42 Mailbox Shenyang Pharmaceutical University
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Li Lei
School Of Materials Science And Engineering Liaocheng University
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Zhao Xiu-Li
School of Pharmacy 42 Mailbox, Shenyang Pharmaceutical University
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LI Lei
School of Information Science & Engineering and Shandong Provincial Key Laboratory of Laser Technology and Application, Shandong University
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