Evaluation of Tetrandrine Sustained Release Calcium Alginate Gel Beads In Vitro and In Vivo
スポンサーリンク
概要
- 論文の詳細を見る
An approach for the preparation of tetrandrine sustained release calcium alginate gel beads was described. In vitro the release of tetrandrine from sustained release dosage forms went on a time of 12 hours which fitted non-Fickian diffusion with matrix erosion significantly. In vivo the plasma concentration of tetrandrine extended preparation given in dogs reached Cmax 2.67±0.69 μg/ml approximately at 5.67±0.58 h after oral administration. The AUC0→24 and AUC0→∞ were 24.64±6.77 mg·h/l and 29.75±5.30 mg·h/l, respectively. The elimination half-time was 9.6±2.40 h. While a favorable correlativity existed between in vitro and in vivo with a correlative coefficient of 0.9798 through linear regression. An investigation on the quantitative relationship between in vitro release and in vivo absorption is a highly necessary work guided for manufacture, optimization and in vivo evaluation of sustained release dosage by means of in vitro release or dissolution tests.
- 公益社団法人 日本薬学会の論文
著者
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Chen Da-Wei
School of Pharmacy, Shenyang Pharmaceutical University
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Chen Da-wei
School Of Pharmacy 42 Mailbox Shenyang Pharmaceutical University
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MA Yan
College of Chinese Traditional Medicine, Guangzhou University of Chinese Medicine
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LI Wei-Zhong
Guangdong Baiao Pharmaceutical Co. Ltd.
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GUAN Shi-Xia
College of Chinese Traditional Medicine, Guangzhou University of Chinese Medicine
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LAI Xiao-Ping
College of Chinese Traditional Medicine, Guangzhou University of Chinese Medicine
関連論文
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- Evaluation of Tetrandrine Sustained Release Calcium Alginate Gel Beads In Vitro and In Vivo