Effects of Dried Brewer’s Yeast on Skin and QOL : A Single-Blind Placebo-Controlled Clinical Study of 8-Week Treatment

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Objective: Brewer’s yeast contains vitamins, minerals, amino acids and other nutrients, and has been reported to control intestinal function as well as to exert anti-ulceration, anti-tumor and anti-allergy effects. The present study evaluated the effects of oral treatment with dried brewer’s yeast tablets (study product) on skin in a single-blind placebo-controlled design in humans.Methods: Thirty-two healthy volunteer women (37.0±4.8 years) were allocated as follows: Group E-30 (n=11) were treated with 30 tablets/day of the study product (containing 7,125mg/day of dried brewer’s yeast), Group E-9 (n=10) were given 9 tablets/day of the study product, and the control group (n=11) were given 30 placebo tablets/day. The treatment period was 8 weeks. Two patients prematurely discontinued the study (discontinuation rate: 5.9%) and were excluded from the analyses. The study product (Ebios Tablet®) was provided by Asahi Food & Healthcare Co., Ltd. Before and at 4 and 8 weeks after the study, subjective symptoms were evaluated using the Anti-Aging QOL Common Questionnaire (AAQol) and checking skin symptoms, skin images were analyzed with SK Info (SKI, Integral Co.) and Aphrodite-III (PSI), and skin color (CM-700d, Konica Minolta Sensing, Inc.) and elasticity (Cutometer MPA580, Courage & Khazaka electronic GmbH) were measured.Results: In Group E-30, the AAQol physical symptom “cold skin” score was significantly improved at 8 weeks (p‹0.05). The skin symptoms “make-up runs easily” and “desiccated and gritty skin,” as well as the physical symptom “menstruation-related troubles” were improved in a significant and dose-dependent way from the control group (p‹0.01). On skin analysis, SKI demonstrated an increase in moisture content (15.4%, p=0.010), decrease in erythema (−18.3%, p‹0.001) and increase in elasticity (13.3%, p=0.003), while PSI revealed an increase in hydration (Total: 14.5%, T zone: 13.7%, U zone: 18.2%, p‹0.01) and decrease in pores (− 32.7%, p=0.022). Cutometer analysis showed a dose-dependent increase in skin elasticity, while analysis of skin color showed a decrease in hemoglobin (−9.5%, p=0.016), improved lightness (− 0.7%, p=0.045) and decrease in redness (−8.3%, p=0.013). During the study period, no serious adverse events were noted.Conclusion: These results suggest that treatment with dried brewer’s yeast is useful in improving skin condition, e.g. moisture content and elasticity, and also QOL.

Effects of Dried Brewer’s Yeast on Skin and QOL : A Single-Blind Placebo-Controlled Clinical Study of 8-Week Treatment

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