Herbal extracts inhibit Maillard reaction, and reduce chronic diabetic complications risk in streptozotocin-induced diabetic rats
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概要
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Objectives: Accumulation of end-stage products of the Maillard reaction, also called advanced glycation end products (AGEs), is a hallmark of aging and the pathogenesis of chronic diabetic complications. The aim of this study was to determine whether safe and effective substances contained in four extracts of foodstuffs might slow the development of diabetic complications as well as slow the progression of aging.Design: We evaluated the in-vitro activity of four extracts of dried herbs available in Japan (<I>Anthemis nobilis, Crataegus oxyacantha, Houttuynia coradata, Vitis vinifera</I>) and a mixture of these to inhibit the Maillard reaction. We also assessed whether a 12-week feeding of mixed herbal extract (MHE) admixed in MF chow to streptozotocin (STZ)-induced diabetic rats prevented the development of diabetic complications.Results: Each of the four herbal extracts as well as the mixed extract dose-dependently inhibited the generation of Maillard reaction products in vitro with a potency similar to that of aminoguanidine (AG), a drug used for treating diabetic complications. Furthermore, after a 12-week, MHE supplemental feeding to STZ-induced diabetic rats, serum pentosidine and N<SUP>ε</SUP>-(carboxymethyl)lysine levels and wet weight of the kidney tended to decrease. MHE elicited AG-like actions and produced an inhibitory effect on pentosidine generation at lower concentrations than those observed for AG.Conclusion: Through the inhibition of the Maillard reaction, MHE may slow the development of chronic diabetic complications as well as slow the progression of aging.
- 一般社団法人 日本抗加齢医学会の論文
著者
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Yagi Masayuki
ARKRAY, Inc.
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Yonei Yoshikazu
Anti-aging Medical Research Center Graduate School Of Life And Medical Science Doshisha University
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Matsuura Nobuyasu
Okayama University of Science, Faculty of Science
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Hibino Sawako
Anti-Aging Medical Research Center, Faculty of Life and Medical Science, Doshisha University
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Hibino Sawako
Anti-Aging Medical Research Center, Doshisha University
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Yonei Yoshikazu
Anti-Aging Medical Research Center, Faculty of Life and Medical Science, Doshisha University
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Yonei Yoshikazu
Anti-Aging Medical Research Center and Glycation Stress Research Center, Graduate School of Life and Medical Sciences, Doshisha University
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Yagi Masayuki
ARKRAY Inc.
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- Herbal extracts inhibit Maillard reaction, and reduce chronic diabetic complications risk in streptozotocin-induced diabetic rats