The Role of N-Terminal Pro-B-Type Natriuretic Peptide in the Diagnosis of Congestive Heart Failure in Children : – Correlation With the Heart Failure Score and Comparison With B-Type Natriuretic Peptide –

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概要

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• Background: Both B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) are useful biomarkers for the assessment of congestive heart failure (CHF) in adults. The purpose of this study was to determine whether BNP and NT-proBNP levels could be used to stratify the severity of CHF in children. Methods and Results: The study comprised 181 children with CHF and 232 healthy children aged from 4 months to 14 years who were categorized into CHF grades I, II, III and IV according to the modified Ross scoring system. The plasma BNP and serum NT-proBNP levels were significantly correlated with increasing CHF grades. The NT-proBNP levels were significantly different among the 4 CHF grades. However, only 2 significant differences were observed in the BNP levels between each CHF grade. NT-proBNP testing with cut-off points of >438 pg/ml (≥grade II), >1,678 pg/ml (≥grade III) and >7,734 pg/ml (grade IV) in the patients below 3 years of age, and >295 pg/ml (≥grade II), >1,545 pg/ml (≥grade III) and >3,617 pg/ml (grade IV) in those above 3 years of age was determined to be highly sensitive and specific by receiver operating characteristic analysis. Conclusions: The blood levels of BNP and NT-proBNP therefore reflect the severity of CHF in children. In particular, NT-proBNP is a useful biomarker for evaluating CHF in children.

著者

• Goh Kazutomo

  Department of Emergency Medicine, Asahikawa Medical University

• Fujieda Kenji

  Department of Pediatrics, Asahikawa Medical College

• SUGIMOTO Masaya

  Department of Pediatrics, Asahikawa Medical College

• MANABE Hiromi

  Department of Pediatrics, Asahikawa Medical College

• NAKAU Kouichi

  Department of Pediatrics, Asahikawa Medical College

• FURUYA Akiko

  Department of Pediatrics, Furano Kyokai Hospital

• OKUSHIMA Kasumi

  Department of Pediatrics, Furano Kyokai Hospital

• FUJIYASU Hiroaki

  Department of Pediatrics, Furano Kyokai Hospital

• KAKUYA Fujio

  Department of Pediatrics, Furano Kyokai Hospital

• KAJINO Hiroki

  Department of Pediatrics, Asahikawa Medical College

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