In vitro Biological Activity of Salvia leriifolia Benth Essential Oil Relevant to the Treatment of Alzheimer’s Disease
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概要
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In this study the chemical composition, cholinesterase inhibitory property and anti-inflammatory activity of S. leriifolia Benth. essential oil was evaluated for the first time. GC and GC-MS analysis revealed the presence of camphor (10.5%), 1,8-cineole (8.6%), camphene (6.2%) and α-pinene (4.7%) as main constituents. S. leriifolia oil exhibited a promising antioxidant activity by DPPH assay with an IC50 2.26 μL/mL. Interesting cholinesterase inhibitory activity was also found with IC50 values of 0.32 and 0.29 μL/mL for acetylcholinesterase (AChE) and butyrrylcholinesterase (BChE), respectively. Moreover, this oil inhibited LPS-induced NO production with an IC50 value of 165 μg/mL. The absence of cytotoxicity at 1000 μg/mL was evaluated by MTT assay in 142BR cells.
著者
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Loizzo Monica
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, Universit
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Menichini Federica
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, Universit
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Tundis Rosa
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, Universit
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Bonesi Marco
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, Universit
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Conforti Filomena
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, Universit
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Nadjafi Farsad
Medicinal Plants and Drugs Research Institute, Shahid Beheshti University
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Statti Giancarlo
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, Universit
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Frega Natale
Department of Food Science, Politecnica delle Marche Universit
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Menichini Francesco
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, Universit
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Loizzo Monica
Department Of Pharmaceutical Sciences University Of Calabria
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Bonesi Marco
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria
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Statti Giancarlo
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria
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Menichini Francesco
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria
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Menichini Federica
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria
関連論文
- In vitro Biological Activity of Salvia leriifolia Benth Essential Oil Relevant to the Treatment of Alzheimer’s Disease
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