Development of Positron-Emission Tomography/Single-Photon Emission Computed Tomography Imaging Probes for in Vivo Detection of β-Amyloid Plaques in Alzheimers Brains
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概要
- 論文の詳細を見る
Currently, the development of radiotracers for in vivo imaging of β-amyloid plaques in Alzheimers disease (AD) brains is an important, active area of molecular imaging. Postmortem brains of AD patients reveal neuropathologic features: the presence of β-amyloid plaques and neurofibrillary tangles, which contain β-amyloid peptides and highly phosphorylated tau proteins. Increases in the concentration of β-amyloid in the course of the disease lead to changes in AD brains. Thus, when used in combination with positron-emission tomography/single-photon emission computed tomography (PET/SPECT), β-amyloid imaging agents could serve as surrogate markers for the early diagnosis and neuropathogenetic studies of AD. Furthermore, quantitative evaluation of β-amyloid plaques in the brain could facilitate the evaluation of the efficacy of antiamyloid therapies that are currently being investigated. This paper reviews our research on the development of PET/SPECT imaging agents for in vivo detection of β-amyloid plaques in Alzheimers brains.
- 公益社団法人 日本薬学会の論文
著者
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Ono Masahiro
Department Of Applied Physics Faculty Of Engineering Osaka University
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Ono Masahiro
Department of Patho-Functional Bioanalyses, Graduate School of Pharmaceutical Sciences, Kyoto University
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