Familial Graves Disease Associated with Type 1 Diabetes
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概要
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A 59-year-old woman was diagnosed as having Graves disease and type 1 diabetes. DNA molecular HLA typing detected DRB1*0405 and DQB1*0401, as well as the haplotypes of DRB1*0901-DQB1*0303. We also performed polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to identify allele variations of other loci. The patients son also manifested Graves disease and type 1 diabetes, with both cases having strikingly homologous clinical features. Familial clustering of Graves disease and type 1 diabetes, and their tendency to occur together along with a similar clinical course suggest that their etiology may involve shared genetic factors.
著者
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NEMOTO Masami
Division of Diabeters, Metabolism and Endocrinology, Department of Internal Medicine, Jikei Universi
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Matoba Keiichiro
Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Jikei University S
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Tojo Katsuyoshi
Division Of Diabetes And Endocrinology Department Of Internal Medicine Jikei University School Of Me
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Tajima Naoko
Division Of Diabeters Metabolism And Endocrinology Department Of Internal Medicine Jikei University
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Nemoto Masami
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine
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Tojo Katsuyoshi
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine
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