CLOCK:BMAL-Independent Circadian Oscillation of Zebrafish Cryptochrome1a Gene
スポンサーリンク
概要
- 論文の詳細を見る
In the vertebrate circadian feedback loop, CLOCK:BMAL heterodimers induce the expression of Cry genes. The CRY proteins in turn inhibit CLOCK:BMAL-mediated transcription closing the negative feedback loop. Four CRYs, which all inhibit CLOCK:BMAL-mediated transcription, exist in zebrafish. Although these zebrafish Crys (zCry1a, 1b, 2a, and 2b) show a circadian pattern of expression, previous studies have indicated that the circadian oscillation of zCry1a could be CLOCK:BMAL-independent. Here we show that abrogation of CLOCK:BMAL-dependent transcription in zebrafish cells by the dominant negative zCLOCK3-DeltaC does not affect the circadian oscillation of zCry1a. Moreover, we provide several lines of evidence indicating that the extracellular signal-regulated kinase (ERK) signaling cascade modulates the circadian expression of zCry1a gene in constant darkness. Taken together, our data strongly support the notion that circadian oscillation of zCry1a is CLOCK:BMAL-independent and further indicate that mechanisms involving non-canonical clock genes could contribute to the circadian expression of zCry1a gene in a cell autonomous manner.
- 公益社団法人 日本薬学会の論文
著者
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Nishina Hiroshi
Department of Developmental and Regenerative Biology Medical Research Institute Tokyo Medical and De
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TAKAMATSU KEN
Department of Physiology, Keio University School of Medicine
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Takamatsu Ken
Department Of Biophysics And Biochemistry Faculty Of Science Universiiy Of Tokyo
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Hirayama Jun
Medical Top Track Program, Medical Research Institute, Tokyo Medical and Dental University
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Miyamura Norio
Department of Developmental and Regenerative Biology, Tokyo Medical and Dental University
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Sawanobori Kenji
Department of Developmental and Regenerative Biology, Tokyo Medical and Dental University
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Tamaru Teruya
Department of Physiology, Toho University School of Medicine
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Asaoka Yoichi
Department of Developmental and Regenerative Biology, Tokyo Medical and Dental University
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Honda Reiko
Medical Top Track Program, Medical Research Institute, Tokyo Medical and Dental University
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Yamamoto Takuro
Life Science Laboratory, Advanced Materials Laboratories, Sony Corporation
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Uno Hatsume
Life Science Laboratory, Advanced Materials Laboratories, Sony Corporation
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Asaoka Yoichi
Department Of Biophysics And Biochemistry Graduate School Of Science The University Of Tokyo
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NISHINA Hiroshi
Department of Development and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University
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