Mechanisms of Synergistic Skin Penetration by Sonophoresis and Iontophoresis
スポンサーリンク
概要
- 論文の詳細を見る
The mechanism of skin penetration enhancement by ultrasound under sonophoresis (US) or by an electrical field under iontophoresis (IP) was investigated using hairless mouse skin in vitro. The seven model chemicals with different molecular weights (122—1485) were dissolved in a hydrophilic gel. Donor gel with the chemicals was loaded on the skin surface and then the skin was treated with US (300 kHz, 5.2 W/cm2, 5.4% duty-cycle) and IP (0.32±0.03 mA/cm2) individually or with US and IP in combination (US+IP). The penetration profiles of the chemicals with a molecular weight of less than 500 were influenced by the presence of an electric charge, the profiles of ionized chemicals for US+IP were the same as profiles for IP, while the penetration flux of a non-ionized chemical synergistically increased with US+IP compared with the individual flux of US and IP. The chemicals with molecular weight of more than 1000 showed synergistic effects with US+IP. The mathematical simulation assuming a bilayer skin model revealed that the synergistic effects were mainly influenced by electroosmosis in the stratum corneum (SC). Therefore the synergistic effects of US+IP was mainly caused by the SC diffusivity of chemicals increased by US and the electroosmotic water flow by IP application.
- 公益社団法人 日本薬学会の論文
著者
-
Hikima Tomohiro
Faculty Of Computer Science And Systems Engineering Kyushu Institute Of Technology
-
Hikima Tomohiro
Kyushu Institute Of Technology College Of Computer Science And Systems Engineering
-
Tojo Kakuji
Faculty Of Computer Science And Systems Engineering Kyushu Institute Of Technology
-
SHIROUZU Kenta
Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology
-
Ohsumi Shinya
Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology
関連論文
- Bioequivalence of Marketed Transdermal Delivery Systems for Tulobuterol(Biopharmacy)
- An Experimental Approach to Study the Binding Properties of Vitamin E(α-Tocopherol) during Hairless Mouse Skin Permeation
- Control of the Barrier Capacity of Stratum Corneum by Microdermabrasion
- Synergistic Effect of Sonophoresis and Iontophoresis in Transdermal Drug Delivery
- Mechanisms of Synergistic Skin Penetration by Sonophoresis and Iontophoresis
- A Pharmacokinetic Model for Ocular Drug Delivery
- Effects of Pathological Conditions on Ocular Pharmacokinetics of Antimicrobial Drugs