Expression of mRNA for 5-HT2 Receptors and Proteins Related to Inactivation of 5-HT in Mouse Osteoblasts
スポンサーリンク
概要
- 論文の詳細を見る
We analyzed the expression of 5-HT2 receptors and proteins related to inactivation of 5-HT in primary cultures of mouse osteoblasts. The mRNA for the 5-HT2A receptor was detectable in anaplastic osteoblasts as well as in differentiated and matured osteoblasts. The mRNA for the 5-HT2B receptor and 5-HT transporter was undetectable in anaplastic osteoblasts and became detectable in differentiated and matured osteoblasts. It was suggested that 5-HT might regulate the proliferation of anaplastic osteoblasts through the 5-HT2A receptor without control by 5-HT–inactivating mechanisms. The differentiation and maturation of osteoblasts might be regulated by the activation of the 5-HT2B receptor under the control of 5-HT inactivation.
著者
-
Nishio Hiroaki
Department Of Molecular Pharmacology Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama Univer
-
HIRAI Takao
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University
-
TOKUMO Kohji
Department of Molecular Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama Univ
-
TSUCHIYA Daijyu
Department of Molecular Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama Univ
-
Hirai Takao
Department Of Molecular Pharmacology Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama Univer
-
Tokumo Kohji
Department Of Molecular Pharmacology Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama Univer
-
Tokumo Kohji
Fac. Of Pharmacy And Pharmaceutical Sciences Fukuyama Univ.
-
Tsuchiya Daijyu
Department Of Molecular Pharmacology Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama Univer
-
Hirai Takao
Department Of Molecular Pharmacology Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama Univer
-
Tokumo Kohji
Department of Molecular Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan
-
Tsuchiya Daijyu
Department of Molecular Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan
-
Nishio Hiroaki
Department of Molecular Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan
関連論文
- Expression of mRNA for 5-HT_2 Receptors and Proteins Related to Inactivation of 5-HT in Mouse Osteoblasts
- Expression of mRNA for 5-HT2 Receptors and Proteins Related to Inactivation of 5-HT in Mouse Osteoblasts
- Molecular modeling of the interaction of sarpogrelate and human 5-HT_, 5-HT_ and 5-HT_ receptor subtypes
- Transactivation of Core Binding Factor α1 as a Basic Mechanism to Trigger Parathyroid Hormone-Induced Osteogenesis
- Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions : Gene Expression in Response to Static Magnetism in Cultured Rat Hippocampal Neurons
- 5-HT-Induced, 5-HT_3 Receptor-Mediated, and Ruthenium Red- and Capsaicin-Sensitive Positive Chronotropic Effects in the Isolated Guinea Pig Atrium
- INTERACTIONS OF β-ADRENOCEPTOR BLOCKING AGENTS WITH SEROTONIN RECEPTOR SUBTYPES-SPECIAL REFERENCE TO THEIR PROPHYLACTIC EFFECT ON MIGRAINE
- Inhibitory Effect of EGTA on Serotonin Transport into Rabbit Blood Platelets: Possible Involvement of the Glycoprotein IIb/IIIa Complex
- Effects of Perinatal Stress on the Emotion-Related Behavior of the Adolescent Mouse(Pharmacology)
- EFFECT OF COLD TREATMENT AND SOME DRUGS ON THE 5-HYDROXYTRYPTAMINE UPTAKE BY RABBIT BLOOD PLATELETS AND THEIR ULTRASTRUCTURE
- EFFECT OF CONCANAVALIN A ON 3H-5-HYDROXYTRYPTAMINE UPTAKE IN RABBIT BLOOD PLATELETS: INTERACTION WITH ADENYLATE CYCLASE ACTIVITY
- PROTECTIVE ACTION OF GUANETHIDINE ON ATRIA ISOLATED FROM RESERPINIZED RABBITS DURING EXPOSURE TO SODIUM-DEFICIENT MEDIA
- A new guanidine derivative: Dissociation of the adrenergic neuron blocking activity from local anesthetic activity.
- Isolation of Substance P Binding Protein from Rat Brain.
- Effect of concanavalin A on 5'-nucleotidase activity of rabbit blood platelets.
- Effect of Concanavalin A on Intracellular Calcium Concentration in Single Blood Platelets.