Pigment Epithelium-derived Factor as a New Diagnostic Marker for Melanocytic Tumors
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概要
- 論文の詳細を見る
Pigment epithelium-derived factor (PEDF), a potent antiangiogenetic factor, has been lately known to correlate well with angiogenic and metastatic potentials of tumor cells. We investigated the expression of PEDF protein in various types of human tumor cells by an immunohistochemical technique using a monoclonal antibody. Consequently, we found the significantly frequent and intense expression of PEDF in human melanocytic tumor cells including malignant melanoma as compared to non-melanocytic ones. We evaluated the diagnostic usefulness of anti-PEDF antibody in melanocytic tumors by comparing its immunoreactive sensitivity with that of other conventional melanocytic markers such as S-100 protein, HMB-45 and Melan-A, and found that PEDF possess the equal ability to others on its sensitivity. We finally concluded that PEDF is a useful diagnostic marker for melanocytic tumors, especially malignant melanomas, by its use in combination with other markers.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Kato Seiya
Department Of Neurosurgery Ohara Medical Center:m.d. Department Of Emergency And Critical Care Medic
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Arima Nobuyuki
Department Of Clinical Pathology Kumamoto City Hospital
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TOYOZUMI Yasuo
Department of Clinical Pathology, Kumamoto City Hospital
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TOYOZUMI YASUO
Department of Pathology, Saitama Medical University, Saitama Medical Center
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TSURU MASAKI
Department of Pathology, Kurume University School of Medicine
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