Aberrant expression of sialidase and cancer progression

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概要

• 論文の詳細を見る

• Aberrant sialylation is closely associated with the malignant phenotype of cancer cells including metastatic potential and invasiveness. However, its biological significance and molecular mechanisms have yet to be fully elucidated. To determine causes and consequences, we have focused attention on mammalian sialidases, which cleave sialic acids from gangliosides and glycoproteins. The four types of human sialidases identified to date behave in different manners during carcinogenesis. One, found in the lysosomes, shows down-regulation in cancers, promoting anchorage-independent growth and contributing to metastatic ability, while another, found in the plasma membranes, exhibits marked up-regulation, resulting in suppression of apoptosis. The present review summarizes mostly our results on aberrant expression of sialidases and their possible roles in cancer progression.(Communicated by Takao SEKIYA, M.J.A.)

• 日本学士院の論文

著者

• Miyagi Taeko

  宮城県立がんセンター研究所 生化学部

• Miyagi Taeko

  Division Of Biochemistry Miyagi Cancer Center Research Institute

関連論文

• Plasma Membrane-associated Sialidase as a Crucial Regulator of Transmembrane Signalling
• Down-regulation of sialidase NEU4 may contribute to invasive properties of human colon cancers
• Plasma membrane-associated sialidase (NEU3) promotes formation of colonic aberrant crypt foci in azoxymethane-treated transgenic mice
• シアリダーゼとその機能
• Aberrant expression of sialidase and cancer progression

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