Outline of disease gene hunting approaches in the Millennium Genome Project of Japan

スポンサーリンク

概要

• 論文の詳細を見る

• To capture the potentially enormous and vital opportunity in the post sequence era of human genome research, the Japanese government on December 19, 1999 drew up the basic outlines of the 5-year Millennium Genome Project (MGP). The “Disease Gene” Team of MGP aims to establish genome-based personalized medical care and to seed a revolutionary drug development inspired by the new information and technology, which the genome research provides. Five disease categories have been chosen as project targets: dementia, cancer, diabetes, hypertension and asthma, which are manifesting a major impact on the health and welfare of the rapidly graying Japanese society. These so-called “common diseases” are etiologically multifactorial, and the genetic components, if any, are considered polygenic with relatively high disease allele frequencies in the population. In the first year, 2000, a consortium or “Subteam” was established for each disease category, and several hypothesis-driven candidate gene approaches were launched. In 2001, a complementary strategy of disease gene hunting, a statistics-based genome-wide approach, was initiated. The Disease Gene Team decided to employ a genome-wide, gene-based SNP scan through close collaboration with another arm of MGP, the “Human Genome Variation” Team, which discovered 194, 393 SNPs as of December 25, 2002 from genome of the Japanese people. Each Subteam reached a consensus regarding eligibility criteria and research protocols, which were reviewed by the institutional review boards in accordance with the new Ethics Guidelines For Human Genome/Genetic Analysis Research promulgated by the government on April 1, 2001. The Subteams organized a multi-institutional consortium, which in 2001 collaborated in the collection of quality germline DNA samples and clinical and life-style related information. In 2002, the third year of MGP, the genome scan started at two typing centers using the high-throughput SNP typing system established by RIKEN. The premise and prospect of the approach will be discussed.(Communicated by Takashi SUGIMURA, M. J. A., Feb. 12, 2003)

• 日本学士院の論文

著者

• Yoshida Teruhiko

  Genetic Counseling Clinic National Cancer Center Hospital

• Yoshimura Kimio

  Cancer Information And Epidemiology Division National Cancer Center Research Institute

関連論文

• Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences
• Identification of Genetic Markers Associated With High-Density Lipoprotein-Cholesterol by Genome-Wide Screening in a Japanese Population : The Suita Study
• Twelve Novel Single Nucleotide Polymorphisms in the CES2 Gene Encoding Human Carboxylesterase 2 (hCE-2)
• 日本人におけるGSTT1及びGSTM1の遺伝子多型の同定及びハプロタイプ構造の解析
• Twenty Novel Genetic Variations and Haplotype Structures of the DCK Gene Encoding Human Deoxycytidine Kinase (dCK)
• Fourteen Novel Genetic Variations and Haplotype Structures of the TYMS Gene Encoding Human Thymidylate Synthase (TS)
• 日本人におけるヒトSLC29A1の新規遺伝子多型の同定
• Genetic Variation and Haplotype Structure of the ABC Transporter Gene ABCG2 in a Japanese Population
• Genetic Variations and Haplotypes of UGT1A4 in a Japanese Population
• Genetic Polymorphisms of UGT1A6 in a Japanese Population
• Genetic Variations of the AHR Gene Encoding Aryl Hydrocarbon Receptor in a Japanese Population
• Three Novel Single Nucleotide Polymorphisms in UGT1A9
• Novel Genetic Polymorphisms in the NR3C1 (Glucocorticoid receptor) Gene in a Japanese Population
• Twenty-six Novel Single Nucleotide Polymorphisms and their Frequencies of the NR113 (CAR) Gene in a Japanese Population
• Eight Novel Single Nucleotide Polymorphisms in ABCG2/BCRP in Japanese Cancer Patients Administered Irinotacan
• Three novel single nucleotide polymorphisms in UGT1A10
• Cross-sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer
• Outpatient clinic for genetic counseling and gene testing of retinoblastoma
• Administration route-dependent induction of antitumor immunity by interferon-alpha gene transfer
• Local interferon-α gene therapy elicits systemic immunity in a syngeneic pancreatic cancer model in hamster
• Prognostic Factor Analysis of Early Death in Stage II Breast Cancer
• Association of a missense single nucleotide polymorphism, Cys1367Arg of the WRN gene, with the risk of bone and soft tissue sarcomas in Japan
• The confidence interval of allelic odds ratios under the Hardy-Weinberg disequilibrium
• Designing a multistage, SNP-based, genome screen for common diseases
• Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes : data from random population-based Japanese samples
• Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate genes for gene-environment studies on cancer : data from population-based Japanese random samples
• Genetic Structure of the Five-factor Model of Personality in a Japanese Twin Population
• Health Consciousness of Young People in Relation to their Personality
• Effects of Sarin on the Nervous System of Subway Workers Seven Years after the Tokyo Subway Sarin Attack
• Adrenocorticotropin-Independent Macronodular Adrenocortical Hyperplasia Associated with Multiple Colon Adenomas/Carcinomas Which Showed a Point Mutation in the APC Gene
• Genetic Polymorphisms of Copper- and Platinum Drug-efflux Transporters ATP7A and ATP7B in Japanese Cancer Patients
• Classification of Intramural Metastases and Lymph Node Metastases of Esophageal Cancer from Gene Expression Based on Boosting and Projective Adaptive Resonance Theory(BIOINFORMATICS)
• Schizophrenia : Is it time to replace the term?
• Identification of the CAB2/hCOS16 Gene Required for the Repair of DNA Double-strand Breaks on a Core Amplified Region of the 17q12 Locus in Breast and Gastric Cancers
• Genome-wide germline analyses on cancer susceptibility and GeMDBJ database : Gastric cancer as an example
• Personality Assessment Based on the Five-factor Model of Personality Structure in Patients with Primary Open-Angle Glaucoma
• Absence of Germline CHK2 Mutations in Familial Gastric Cancer
• Epidemiology of suicidal ideation and help-seeking behaviors among the elderly in Japan
• Genetic Polymorphisms of FCGRT Encoding FcRn in a Japanese Population and Their Functional Analysis
• Development of gene therapy to target pancreatic cancer
• Outline of disease gene hunting approaches in the Millennium Genome Project of Japan
• The Psychological Characteristcs of Tobacco Dependence in a Rural Area of Japan
• Relationship of detection rate of PET cancer screening examinees and risk factors : analysis of background of examinees
• ECONOMIC ASPECTS OF SOMATOFORM DISORDERS IN JAPAN
• REV1 Genetic Polymorphisms and Breast Cancer Risk in Thai Women
• Detection of inappropriate samples in association studies by an IBS-based method considering linkage disequilibrium between genetic markers
• Production of Phytoene, an Oxidative Stress Protective Carotenoid, in Mammalian Cells by Introduction of Phytoene Synthase Gene crtB Isolated from a Bacterium Erwinia uredovora.

もっと見る 閉じる

スポンサーリンク