Primary Pulmonary Squamous Cell Carcinoma Associated with Elevated IL-6, Leukocytosis, Hypercalcemia, Phagocytosis, Reactive Lymphadenopathy and Glomerular Mesangial Cell Proliferation via the Production of PTH-rP and G-CSF
スポンサーリンク
概要
- 論文の詳細を見る
We report an autopsied case of a 74-year-old man with primary pulmonary squamous cell carcinoma (SCC) associated with leukocytosis, hypercalcemia, phagocytosis in the bone marrow, reactive lymphadenopathy and mesangial cell proliferation in the glomerulus. Laboratory examination revealed increased serum levels of parathyroid hormone-related peptide (PTH-rP), granulocyte colony stimulating factor (G-CSF), interleukin-6 (IL-6) and soluble interleukin 2 receptor (s-IL2R). An autopsy showed moderately differentiated SCC at the left lower lobe of the lung, of which tumor cells distinctly showed cytoplasmic immunoreactivity to anti-G-CSF and anti-PTH-rP antibodies. Thus, pulmonary SCC seemed to produce both G-CSF and PTH-rP, causing leukocytosis, hypercalcemia, and IL-6 production from the bone. IL-6 also might have stimulated the proliferation of SCC and glomerular mesangial cells, and induced phagocytosis, reactive lymphadenopathy and hepatosplenomegaly by interacting with the mononuclear phagocytic system.
著者
-
Yamane Yuko
Department Of Endocrinology/metabolism And Hematology/oncology Shimane University Faculty Of Medicin
-
Sugimoto Toshitsugu
Department Of Endocrinology And Metabolism Faculty Of Medicine Shimane University
-
Yamaguchi Toru
Department of Electronic System Engineering, Tokyo Metropolitan Institute of Technology
-
Takaoka Shin
Department of Internal Medicine 1, Shimane University Faculty of Medicine
-
Nishiki Masateru
Department of Internal Medicine 1, Shimane University Faculty of Medicine
-
Yamane Yuko
Department of Internal Medicine 1, Shimane University Faculty of Medicine
-
Yamaguchi Toru
Department of Internal Medicine 1, Shimane University Faculty of Medicine
関連論文
- Vanished Islands and Hidden Continents of the Pacific, By Patrick D. Nunn, University of Hawai'i Press, Honolulu, 2009, 269 pp., ISBN:9780824832193
- Lymph node lesion in infectious mononucleosis showing geographic necrosis containing cytologically atypically B-cells. A case report
- Causes and Differential Diagnosis of Hypocalcemia : Recommendation Proposed by Expert Panel Supported by Ministry of Health, Labour and Welfare, Japan
- On the Global Asymptotic Stability Independent of Delay of Neural Networks
- On the Absolute Exponential Stability of Neural Networks with Globally Lipschitz Continuous Activation Functions
- A Remark on a Class of Stability Conditions for Neural Networks
- A Case of Idiopathic Hypoparathyroidism Associated with Sensorineural Deafness and Mental Retardation
- Differential labeling of the pinealocytes and pineal interstitial cells by a series of monoclonal antibodies to human pineal body
- Vitamin D Status Affects Osteopenia in Postmenopausal Patients with Primary Hyperparathyroidism
- The Threshold of Bone Mineral Density for Vertebral Fracture in Female Patients with Glucocorticoid-induced Osteoporosis
- An elderly patient with type 2 diabetes mellitus complicated with diabetic nephropathy and lupus nephritis
- On the Analysis of Global and Absolute Stability of Nonlinear Continuous Neural Networks
- Serum DHEA-S Level Is Associated with the Presence of Atherosclerosis in Postmenopausal Women with Type 2 Diabetes Mellitus
- Determination of serum c-peptide (CPR) and urinary excretion of CPR as an indicator for introducing intensive insulin treatment in patients with diabetes mellitus
- A Case of Magnesium Deficiency Associated with Insufficient Parathyroid Hormone Action and Severe Osteoporosis
- Acromegaly Associated with Monoclonal Gammopathy of Undetermined Significance (MGUS)
- Immunohistochemical characterization of pineal parenchymal tumors using novel monoclonal antibodies to the pineal body
- MPO-ANCA-positive IgA nephropathy successfully treated with tonsillectomy
- Bone metabolism after cinacalcet administration in patients with secondary hyperparathyroidism
- A Case of Idiopathic Hypoparathyroidism Associated with Sensorineural Deafness and Mental Retardation
- Japanese Sign Language Recognition System Using Image Processing
- Histopathological Study on the Distribution of Langerhans Cells in Oral Mucosa
- Primary Pulmonary Squamous Cell Carcinoma Associated with Elevated IL-6, Leukocytosis, Hypercalcemia, Phagocytosis, Reactive Lymphadenopathy and Glomerular Mesangial Cell Proliferation via the Production of PTH-rP and G-CSF
- Renal Crisis Due to Intimal Hyperplasia in a Patient with Mixed Connective Tissue Disease (MCTD) Accompanied by Pulmonary Hypertension
- Relationship between treatments with insulin and oral hypoglycemic agents versus the presence of vertebral fractures in type 2 diabetes mellitus
- Vitamin D insufficiency defined by serum 25-hydroxyvitamin D and parathyroid hormone before and after oral vitamin D_3 load in Japanese subjects
- Design of a pragmatic approach to evaluate the effectiveness of concurrent treatment for the prevention of osteoporotic fractures
- Motion Recognition by Architecture of Recomposed Information (第17回ファジィシステムシンポジウム--科学技術と自然の調和を目指して)
- Absolute Exponential Stability of Neural Networks with Asymmetric Connection Matrices
- Optimal Design of Hopfield-Type Associative Memory by Adaptive Stability-Growth Method
- Elcatonin is effective for lower back pain and the symptoms of gastroesophageal reflux disease in elderly osteoporotic patients with kyphosis
- Fasudil hydrochloride induces osteoblastic differentiation of stromal cell lines, C3H10T1/2 and ST2, via bone morphogenetic protein-2 expression
- Rosuvastatin Increased Serum Osteocalcin Levels Independent of Its Serum Cholesterol-Lowering Effect in Patients with Type 2 Diabetes and Hypercholesterolemia
- Chaotic Evolutionary Computation on Intelligent Agents
- Quantitative ultrasound and vertebral fractures in patients with type 2 diabetes
- Hypercalcemia Associated with Eosinophilic Myocarditis in a Patient Undergoing Maintenance Hemodialysis
- Postoperative Distal Adding-on and Related Factors in Lenke Type 1A Curve