Serum Levels of Adipocytokines, Adiponectin and Leptin, in Patients with Obstructive Sleep Apnea Syndrome
スポンサーリンク
概要
- 論文の詳細を見る
Objrctive Obstructive sleep apnea syndrome (OSAS) is frequently complicated by metabolic syndrome, including diabetes and hypertension. Both OSAS and metabolic syndrome are strongly associated with obesity. Recently, adiponectin and leptin, which are secreted by adipose tissue, have been considered to play important roles in the progression of these diseases. Thus, to examine the association between leptin, adiponectin and OSAS, we measured the serum level of these adipocytokines in the same OSAS patients. Methods and Patients Sixty-eight consecutive Japanese men, who recorded all-night polysomnography, were enrolled in this study, and were divided into three groups, control (n=15), moderate OSAS (n=21) and severe OSAS (n=32). We measured serum levels of adiponectin and leptin by ELISA. Results Serum leptin levels were positively correlated with apnea hypopnea index (AHI) (r=0.552, p<0.001), the percentage of time with less than 90% hemoglobin saturation level in total sleep time (%T<90) (r=0.399, p<0.001) and body mass index (BMI) (r=0.807, p<0.0001). These parameters were suggested as the determinant factor for the serum leptin level by stepwise multiple regression analysis. On the other hand, serum adiponectin levels showed a positive correlation with age (r=0.361, p=0.005) and HDL-cholesterol level (r=0.274, p=0.039). Although there was no significant correlation between serum adiponectin levels and AHI or %T<90, serum adiponectin levels were chosen at a determinant factor of %T<90. Conclusion These results suggested that the increasing severity of OSAS induces an increase in setum leptin concentration, but the serum adiponectin levels may be regulated independently of the degree of OSAS, obesity and serum leptin levels in patients with OSAS.
- 社団法人 日本内科学会の論文
著者
-
Yokoyama Tomoyuki
Department Of Human Science Toyoeiwa Women's College
-
Matsui Hiroki
Department Of Biological Science Graduate School Of Science Hiroshima University
-
Sando Yoshichika
Koyagi Clinic
-
Tokuda Fumie
Department of Laboratory Science, Gunma Univercity School of Health Sciences
-
Koike Hiroto
Department of Laboratory Science, Gunma Univercity School of Health Sciences
-
Yokoyama Tomoyuki
Department of Laboratory Science, Gunma Univercity School of Health Sciences
関連論文
- PJ-118 Runx2 Represses TGF β/Smad-mediated Connective Tissue Growth Factor Gene Expression in Vascular Smooth Muscle Cells(PJ020,Atherosclerosis, Basic 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Societ
- PJ-228 Osteogenic Transcription Factor Runx2 represses Connective Tissue Growth Factor Gene Expression and TGFbeta Signaling in Vascular Smooth Muscle Cells(Atherosclerosis, basic(06)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the
- Prostaglandin F2α Inhibits SERCA2 Gene Transcription Through an Induction of Egr-1 in Cultured Neonatal Rat Cardiac Myocytes
- PJ-191 Capillary-Specific Expression of FABP4 and FABP5 (Fatty Acid Binding Proteins) : A Possible Role of Fatty Acid Transport through Capillary Endothelium(PJ032,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) 1 (H),Poster Session (Japa
- PJ-174 Obesity-Induced Stearoyl-coa Desaturase-1 Plays a Protective Role Against Lipotoxicity in Rat Heart(PJ030,Metabolic Syndrome 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-119 Stearoyl-CoA Desaturase-1 Has a Protective Effect against Saturated Fatty Acids-induced Osteogenic Differentiation and Apoptosis in Vascular Smooth Muscle Cells(PJ020,Atherosclerosis, Basic 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientif
- PJ-092 PIAS1 Mediates TGF β-induced SM α-actin Gene Expression through Inhibition of KLF4 Function-expression by Protein Sumoylation(PJ016,Molecular Biology/Genetics, Myocardium, Vascular (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of
- OE-313 A novel hypoxia-inducible gene, DEPP, contributes to shift of energetic metabolism from fatty acids to glucose in cardiac myocytes.(Myocardial ischemia/reperfusion, basic/clinical(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeti
- OE-039 Fatty Acid Binding Protein 4 is a Target Gene of Notch Signaling in Endothelial Cells of Capillaries in Heart.(Endothelium(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-784 Identification of Cardiovascular Cell-specific DEPP as a Target Gene of Notch Signaling(Endothelium-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-360 Fatty Acid Binding Protein 4 is a Target Gene of Notch Signaling in Endothelial Cells of Cardiac Capillaries(Endothelium-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-792 Expression of SOCS-3, and Innhibitor of gp130/Jak/Stat Pathway, is Highly Regulated during Pressure-Overloaded Heart in Rats(Growth factor/Cytokine-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-490 Cardiac Sympathetic Nerve Activation Contributes to Manifestation of Connective Tissue Growth Factor and may Promote Myocardial Fibrosis DCM Patients(Heart failure, clinical-13, The 71st Annual Scientific Meeting of the Japanese Circulation Society
- Leptin Receptor Long Isoform (ob-Rb) is Upregulated in Pressure Overloaded Rat Heart(Diabetes/Obesity 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Ischemia and Reperfusion Induce Leptin, Leptin Receptor and p53 Gene Expression with Apoptosis, and Leptin Directly Stimulates p53 Gene Expression
- OE-110 Elevated Stearoyl-CoA Desaturase-1 Expression in Obese Rat Heart Leads to Myocardial Lipid Accumulation and Metabolic Abnormalities(Diabetes/Obesity/Metabolic syndrome-01, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-437 Mechanical Stretch Directly Up-regulates Expression of Leptin and Long Form Leptin Receptor (ob-Rb) in Neonatal Rat Ventriclar Myocytes(Diabetes/Obesity/Metabolic syndrome-4 (H) PE73,Poster Session (English),The 70th Anniversary Annual Scientific M
- Leptin, Obesity-associated Peptide, Stimulates Collagen Production and Proliferation in Neonatal Rat Cardiac Fibroblasts(Diabetes/Obesity 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-546 Hypoxia and Reoxygenation modified Expression of Leptin and Leptin Receptor isoforms in rat cardiomyocytes.(Myocardial Ischemia-Reperfusion, Basic and Clinical 3 (M) : PJ91)(Poster Session (Japanese))
- A pharmacotherapy algorithm for the treatment of dysthymia in Japan
- Reliability of the 5-min speech sample for assessing expressed emotion in Japanese patients
- Hybrid Gas Bearing with Water Evaporation from Ultra-Fine Porous Medium
- B301 HYBRID GAS BEARING WITH WATER EVAPORATION FROM ULTRA-FINE POROUS MEDIUM
- Construction of physical map and mapping of chromosomal virulence genes of the biovar 3 Agrobacterium (Rhizobium vitis) strain K-Ag-1
- Relation Between Connective Tissue Growth Factor and Cardiac Sympathetic Nerve Activity in Heart Failure in DCM Patients
- Serum Levels of Adipocytokines, Adiponectin and Leptin, in Patients with Obstructive Sleep Apnea Syndrome
- Middle Miocene to Pleistocene planktonic foraminiferal biostratigraphy in the eastern equatorial Pacific Ocean
- Clinical Outcome of Treatments for Spinal Dural Arteriovenous Fistulas : Results of Multivariate Analysis and Review of the Literature