A Rule-Based Computational Study on the Early Progression of Intracranial Aneurysms Using Fluid-Structure Interaction: Comparison between Straight Model and Curved Model
スポンサーリンク
概要
- 論文の詳細を見る
Study of the development of aneurysm is a difficult task due to lack of experimental and clinical data. The current study takes advantage of fluid-structure interaction (FSI) to simulate the formation and growth of aneurysms by focusing on the interplay between the wall shear stress, degeneration of the vessel wall, and the wall deformation. We construct numerical aneurysm models arisen from both straight and curved arteries, under the hypothesis that high local wall shear stress larger than a certain threshold value will lead to a linear decrease in the wall mechanical properties. In the straight model, the growth of aneurysm is small and only at the distal neck region, and the aneurysm stops growing after several steps. In contrast, in the curved model, the aneurysm continues to grow in height and width. Our computer simulation study shows that even if the wall shear stress inside an aneurysm is low, aneurysm development can occur due to degeneration of the wall distal and proximal to the aneurysm. Our study demonstrates the potential utility of rule-based numerical methods in the investigation of developmental biology of cardiovascular diseases.
著者
-
Yamaguchi Takami
Department Of Bioengineering And Robotics Graduate School Of Engineering Tohoku University
-
Tsubota Ken-ichi
Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University
-
Wada Shigeo
Department Of Bioengineering And Robotics Graduate School Of Engineering Tohoku University
-
ISHIKAWA Takuji
Department of Bioengineering & Robotics, Graduate School of Engineering, Tohoku University
-
FENG Yixiang
Mechanical Engineering Research Laboratory, Hitachi Ltd.
-
YAMAGUCHI Takami
Department of Bioengineering & Robotics, Graduate School of Engineering, Tohoku University
-
TSUBOTA Ken-ichi
Department of Mechanical Engineering, Division of Artificial System Science Graduate School of Engineering, Chiba university
関連論文
- Computational Flow Dynamics in Abdominal Aortic Aneurysm Using Multislice Computed Tomography
- Technical Application of Three-dimensional Visualization and Measurement for Breast Cancer Using Multidetector-row CT Scanner
- Is the Virtual Reality a Gentle Technology for Humans? : An Experimental Study of the Safety Features of a Virtual Reality System (Special Issue on Networked Reality)
- Proposal of a Deformable Erythrocyte Model and Numerical Analysis of Shear Flow of Blood
- Numerical Simulation of Stress Fiber Orientation in Cultured Endothelial Cells under Biaxial Cyclic Deformation Using the Strain Limit Hypothesis(Proceedings of the Switzerland-Japan Workshop on New Directions in Cellular and Tissue Biomechanics)(Special
- MR imaging of thymic epithelial tumors : correlation with World Health Organization classification
- Air Microbubbles as MR Susceptibility Contrast Agent at 1.5 Tesla
- Development of a wearable system for monitoring health condition(1E2 Human Dynamics & Stability)
- NUMERICAL SIMULATION OF MALARIA-INFECTED BLOOD FLOW USING A PARTICLE METHOD(3D2 Biorheology & Microcirculation I)
- P-04 MEASUREMENT OF MULTI-RED BLOOD CELLS INTERACTIONS IN BLOOD FLOW BY CONFOCAL MICRO-PTV
- COMPUTATIONAL STUDY OF PLATELET THROMBUS FORMATION IN A BLOOD FLOW(3D2 Biorheology & Microcirculation I)
- P-01 OBSERVATION OF THE BLOOD FLOW IN MICROCHANNEL WITH STENOSIS BY CONFOCAL-MICRO-PIV
- A Rule-Based Computational Study on the Early Progression of Intracranial Aneurysms Using Fluid-Structure Interaction: Comparison between Straight Model and Curved Model
- Simulation Study on Effects of Hematocrit on Blood Flow Properties Using Particle Method
- Effect of non-Newtonian property of blood on flow through a stenosed tube
- PROPOSAL OF MESOSCOPIC ANALYSIS METHOD OF BLOOD RHEOLOGY(3D2 Biorheology & Microcirculation I)
- Quantitative Measurements on the Human Ascending Aortic Flow Using 2D Cine Phase-Contrast Magnetic Resonance Imaging(Bioengineering)
- Computational Fluid Dynamics Study of the Effect of the Left Ventricular Flow Ejection on the Intraaortic Flow(Cardiovascular Mechanics)
- Frame Operator Approach for Designing Discrete-Time Multiple Short-Time Fourier Transform and Its Time-Frequency Distribution (Special Section on Signal Processing for Nonstationary Processes Based on Modelling)
- Improvement of Wavelet Based Parameter Estimations of Nearly 1/f Processes(Digital Signal Processing)
- P-15 Monitoring physical and mental workloads by a wearable computer
- B211 Velocity Measurements of Physiological Flows in Microchannels using a Confocal micro-PIV System
- Mass Transport in Pulsatile Flow through Asymmetric Stenosis
- Vortex enhancement in blood flow through stenosed and locally expanded tubes
- Effect of isokinetic resistance training under a condition of restricted blood flow with pressure
- A Parallel Numerical Method for Bio-Flow Analysis
- MEASUREMENT OF RESPIRATION BY A HYPER DIAPER WITH CONDUCTIVE RUBBER(3C1 Cardiopulmonary & Respiratory Mechanics)
- CFD STUDY ON MASS TRANSPORT TO SACCULAR ANEURYSMS AT ARTERIAL BEND(1D1 Cardiovascular Mechanics I)
- A SIMULATION MODEL FOR CEREBRAL ANEURYSM GROWTH BASED ON A HEMODYNAMIC HYPOTHESIS(1E1 Computational Biomechanics)
- 2TA4-07 ダイニンの力発生に伴う構造変化(分子モーター,第47回日本生物物理学会年会)
- Effects of Pulsation and Geometry on Post-Stenotic Oscillatory Flow
- Computational Simulation of Flow in the Aortic Arch : Influence of the 3-D Distortion on Flows in the Ordinary Helix Circular Tube
- P-45 Biomedical education systems for engineers : REDEEM and ESTEEM projects
- Growth of Intracranial Aneurysms Arised from Curved Vessels under the Influence of Elevated Wall Shear Stress : A Computer Simulation Study(Bioengineering)
- A Particle Method Computer Simulation of the Blood Flow(Micro- and Nano-biomechanics)
- A Computer Simulation on the Growth of Intracranial Aneurysms Arising From a Straight Artery(Cardiovascular flow Simulation)
- Study of Primary Health Care Information System in Indonesia(Biomimetics & Innovative Design)
- Effects of the Initial Orientation of Actin Fibers on Global Tensile Properties of Cells
- Automated Segmentation and Morphometric Analysis of the Human Airway Tree from Multidetector CT Images
- Modeling of the Human Aortic Arch with Its Major Branches for Computational Fluid Dynamics Simulation of the Blood Flow(Reviewed Papers Accepted for Publication in this Special Issue)(Special Issue on Bioengineering)
- Comptational Hemodynamcs Simulation from Very Small Scale to Large Scale
- Formation of Saccular Cerebral Aneurysms May Require Proliferation of the Arterial Wall: Computational Investigation
- Parallel Simulation of Cellular Flow in Microvessels Using a Particle Method
- Patient-specific Morphological and Blood Flow Analysis of Pulmonary Artery in the Case of Severe Deformations of the Lung due to Pneumothorax
- Simulation Study on Local and Integral Mechanical Quantities at Single Trabecular Level as Candidates of Remodeling Stimuli
- A full GPU implementation of a numerical method for simulating capsule suspensions