Myasthenia Gravis and Diabetes Mellitus: -A 35-year Retrospective Study-
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概要
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Background: The most common treatment of myasthenia gravis is high-dose prednisolone administration and thymectomy. A well-known adverse effect of prednisolone is hyperglycemia, however, to date there is no such detailed report. Patients and Methods: We treated 325 myasthenia gravis patients in a recent 35 years period, and found 11 patients with diabetes mellitus. We compared these 11 diabetic patients with previously-reported cases. Results: These 11 patients did not have any antibody against β-cells in the pancreas such as anti-glutamic acid decarboxylase antibody. In 10 of 11 patients diabetes mellitus was controlled with oral medications. Conclusion: Myasthenic patients with diabetes mellitus could be classified into 2 groups, one group with positive organ-specific autoantibodies to many organs (with type 1 diabetes mellitus), and the other group with diabetes mellitus onset during prednisolone administration (with type 2 diabetes mellitus).
- 社団法人 日本内科学会の論文
著者
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Sugimoto Hideki
Department Of Agrobiological Science Faculty Of Agriculture Ehime University
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Nemoto Hiroshi
Department Of Gastroenterological Surgery School Of Medicine Showa University Fujigaoka Hospital
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Nomoto Nobuatsu
Department of Internal Medicine, Division of Neurology, Toho University Ohashi Medical Center, Japan
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Kurihara Teruyuki
Department of Internal Medicine Toho University Ohashi Medical Center, Division of Neurology
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Nakazora Hiroshi
Department of Neurology, Toho University School of Medicine, Oohashi Hospital
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Wakata Nobuo
Department of Neurology, Toho University School of Medicine, Oohashi Hospital
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Konno Shinngo
Department of Neurology, Toho University School of Medicine, Oohashi Hospital
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Sugimoto Hideki
Department of Neurology, Toho University School of Medicine, Oohashi Hospital
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