Recent Advances in the Search for the μ-Opioidergic System : Morphological Studies of the Endomorphinergic Neurons in the Central Nervous System
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概要
- 論文の詳細を見る
Endomorphins (EMs) are newly found endogenous opioid peptides. Both endomorphin-1 (EM-1) and -2 (EM-2) are composed of four amino acids. Their high affinity and specificity for μ-opioid receptors have been confirmed by many physiological and pharmacological studies. In the present minireview, we discuss the distribution and localization of these peptides. While EM-2 is more prevalent in the spinal cord and lower brainstem, EM-1 is more widely and densely distributed throughout the brain than EM-2. We also discuss the possible coexistence of EM with other neurotransmitters. Finally, we introduce some new results regarding the ultrastructure and synaptic relationships of EM-2 obtained by the immunoelectron microscopic method.
- 社団法人 日本薬理学会の論文
- 2002-07-01
著者
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GUAN Jian-Lian
Department of Anatomy, Showa University School of Medicine and the Core Research for Evolutional Sci
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Shioda Seiji
Neuroscience Program Tulane University School Of Medicine
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WANG Qing-Ping
Department of Anatomy, Showa University School of Medicine
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ZADINA James
Department of Veterans Affairs Medical Center
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Guan Jian-lian
Department Of Medicine Tulane University School Of Medicine
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Wang Qing-ping
Department Of Anatomy Showa University School Of Medicine
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Guan Jian-Lian
Department of Anatomy, Showa University School of Medicine
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Zadina James
Department of Medicine and Neuroscience Program, Tulane University School of Medicine and Department of Veterans Affairs Medical Center
関連論文
- Hypothalamic neuronal networks and feeding-related peptides involved in the regulation of feeding
- Recent Advances in the Search for the μ-Opioidergic System : Morphological Studies of the Endomorphinergic Neurons in the Central Nervous System
- The feeding regulation in the hypothalamic neurons
- Recent Advances in the Search for the μ-Opioidergic System : Isolation and Distribution of Endomorphins in the Central Nervous System