Silica-Associated Systemic Lupus Erythematosus in an Elderly Man
スポンサーリンク
概要
- 論文の詳細を見る
The predominantly young woman-orientated systemic lupus erythematosus (SLE) is a disease that involves an extremely complicated and multifactorial interaction of various genetic and environmental factors. Crystalline silica (Si) may act as an immunoadjuvant to increase secretions of inflammatory endogenous substances and antibody production. In addition, previous studies have suggested that exposure to Si may induce SLE. Although the biologic mechanism of Si in SLE is unclear, defective apoptosis leading to the prolonged survival of pathogenic lymphocytes was thought to be one of mechanisms of Si-associated SLE (sSLE). In the present study, a rare case of an elderly man suffering from sSLE responded well to glucocorticoid therapy. The present findings were reviewed with reference to previous literature.
- 社団法人 日本内科学会の論文
著者
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NAGATA ATSUO
Department of Gastroenterology, Nagano Municipal Hospital
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Saito Gaku
Department Of Physics And Research Center For The Early Universe The University Of Tokyo
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Hirai Kazuya
Department Of Internal Medicine Nagano Municipal Hospital
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Hosaka Noriko
Department Of Laboratory Medicine Shinshu University School Of Medicine
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Ehara Takashi
Department Of 1 St Pathology Shinshu University
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Nishimura Hideki
Department Of Applied Physics Faculty Of Science Fukuoka University
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Kakegawa Tetsuji
Department of Internal Medicine, Nagano Municipal Hospital
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Yamazaki Seiichi
Department of Internal Medicine, Nagano Municipal Hospital
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Yoshiike Fumiaki
Department of Internal Medicine, Nagano Municipal Hospital
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Ikeda Michiyo
Department of Internal Medicine, Nagano Municipal Hospital
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