Side Effects of Combination Therapy of Peginterferon and Ribavirin for Chronic Hepatitis-C
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概要
- 論文の詳細を見る
Objective The aim of this study was to elucidate the side effects after combination therapy of peginterferon and ribavirin for Japanese patients with chronic hepatitis C. Methods Inclusion criteria were HCV-genotype 1b and serum HCV RNA level of >100 KIU/ml. Six hundred and twelve patients were received combination therapy and enrolled in this non-randomized prospective cohort study. Patients were monitored until the discontinuation of combination therapy based on treatment-related side effects. The percentage of each medication actually taken during treatment was calculated. Results Sixty-eight patients were stopped the combination therapy due to side effects. The cumulative discontinuation rate due to side effects of therapy was 8.4% at 0.5 year and 14.9% at one year. Discontinuation rate due to side effects was high with statistically significant in the following cases: 1) patients ≥65 years, 2) patients who had diabetes. Sustained viral response (SVR) was 17.6% (12/68) in the discontinuation group. In the discontinuation group, when the percentage of both peginterferon and ribavirin actually taken during treatment was ≥60%, SVR was 31% (9/29). On the other hand, when the percentage of each medication actually taken during treatment was <60%, SVR was 7.7% (3/39). In the discontinuation group, patients with adherence of >60% to the total of scheduled dose tended to have a high SVR compared to those with ≤60% adherence to the total of scheduled dose. Conclusion In combination therapy, patient age and complications of patient are important factors contributing to the safety. In the discontinuation group, patients with adherence of >60% to the total of scheduled dose tend to have a high SVR.
- 社団法人 日本内科学会の論文
著者
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KUMADA Hiromitsu
Department of Hepatology, Toranomon Hospital
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Kumada Hiromitsu
Department Of Gastroenterology Toranomon Hospital
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Sezaki Hitomi
Department Of Hepatology Toranomon Hospital
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Kobayashi Mariko
Hepatic Research Unit, Toranomon Hospital
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Kawamura Yusuke
Department Of Hepatology Toranomon Hospital
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Yatsuji Hiromi
Department Of Hepatology Toranomon Hospital
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Hosaka Tetsuya
Department Of Gastroenterology Toranomon Hospital
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Arase Yasuji
Department Of Gastroenterology Toranomon Hospital
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Akuta Norio
Department Of Gastroenterology Toranomon Hospital
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Suzuki Fumitaka
Department Of Gastroenterology And Metabolism Nagoya City University Graduate School Of Medical Scie
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Ikeda Kenji
Department De Genie Chimique Universite Nationale De Yokohama
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Kobayashi Masahiro
Department Of Chest Surgery Kitakyushu City Yahata Hospital
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Suzuki Yoshiyuki
Department Of Applied Physics Tohoku University
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