Discordant Temporal Changes in Electrophysiological Properties during Electrical Remodeling and Its Recovery in the Canine Atrium
スポンサーリンク
概要
- 論文の詳細を見る
Prolonged rapid atrial excitation gives rise to atrial electrical remodeling, which perpetuates atrial fibrillation (AF). However, there has been controversy regarding the nature of temporal changes in conduction characteristics during the development and recovery of electrical remodeling. This study was designed to clarify the nature of the development and recovery of electrical remodeling in relation to AF inducibility in dogs subjected to rapid atrial pacing. Eleven dogs underwent rapid atrial pacing (400/min) for 28 days. The electrophysiological study was performed on the day just prior to the commencement of pacing, on days 2, 7, 14, and 28 of rapid pacing, as well as 1 and 7 days after the cessation of pacing. In response to rapid atrial pacing, atrial effective refractory period (ERP), conduction velocity and wavelength decreased significantly (p<0.05). ERP had shortened significantly and rapidly within 2 days of pacing, while conduction velocity decreased more gradually. During the recovery, ERP returned to almost baseline levels within a day, whereas conduction velocity returned to baseline by day 7. Sustained AF became inducible in 37% of the dogs from 7 days of pacing until 1 day after the cessation, when wavelength fell below 8.7 cm. In conclusion, rapid atrial excitation causes a progressive but discordant temporal pattern of a decrease in ERP and conduction velocity. The resultant shortening of the wavelength determines the inducibility and maintenance of AF. The electrophysiological changes produced by one month of rapid atrial pacing can be fully reversed within a week, although in a discordant temporal pattern.
- Japanese Heart Journal Associationの論文
著者
-
Ogawa Satoshi
心臓血管研究所
-
Shiroshita Akiko
the Cardiopulmonary Division, Department of Medicine, Keio University School of Medicine
-
Mitamura Hideo
the Cardiopulmonary Division, Department of Medicine, Keio University School of Medicine
-
Shinagawa Kaori
the Cardiopulmonary Division, Department of Medicine, Keio University School of Medicine
-
Sato Toshiaki
the Cardiopulmonary Division, Department of Medicine, Keio University School of Medicine
-
Kurita Yasuo
the Cardiopulmonary Division, Department of Medicine, Keio University School of Medicine
-
Kanki Hideaki
the Cardiopulmonary Division, Department of Medicine, Keio University School of Medicine
-
Takatsuki Seiji
the Cardiopulmonary Division, Department of Medicine, Keio University School of Medicine
-
Hara Motoki
the Cardiopulmonary Division, Department of Medicine, Keio University School of Medicine
-
Ogawa Satoshi
the Cardiopulmonary Division, Department of Medicine, Keio University School of Medicine
-
Kanki Hideaki
慶応義塾大学 循環器内科
関連論文
- ダイジェスト版 心房細動治療(薬物)ガイドライン(循環器病の診断と治療に関するガイドライン(1999-2000年度合同研究班報告))
- 心房細動治療(薬物)ガイドライン(循環器病の診断と治療に関するガイドライン(1999-2000年度合同研究班報告))
- P637 Rotablatorで得られる血管内腔とburrサイズとの関係 : IVUSによる検討
- S-5 心血管Tissue Engineeringを目指した再生心筋細胞の開発
- 植込み型除細動器誤作動の予知 : 過剰感知の原因解析
- 0949 骨髄間質細胞由来の心筋細胞におけるカテコラミン受容体の発現および機能解析
- 心房細動持続時間の電気的除細動後ポーズ長に与える影響
- 電気的リモデリングを受けた心房筋の細動誘発性に対する迷走神経緊張の関与
- 心房高頻度刺激による心房の電気的リモデリングおよび心房細動誘発性の経時的変化
- 1060 心房筋の電気的リモデリングにおける異方向性伝導特性への影響 : 光計測法による検討
- 1059 犬心房筋における異方向性伝導特性と一方向性ブロック及びその加齢による修飾 : 光計測法による検討
- A Consideration on the Orientation of L-Alanine Crystals under a Magnetic Field
- コンゴーレッドとサイクロデキストリン間の各種pHでの相互作用のスペクトル分析
- コンゴーレッドとサイクロデキストリンまたはマルトオリゴ糖間の相互作用のスペクトル分析
- OE-389 Clinical Phenotype of Japanese LQT1 Form of Congenital Long QT Syndrome by Location and Coding Type From Japanese Multicenter Registry(Arrhythmia, diagnosis/Pathophysiology/EPS(02)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of
- Multicenter Prospective Nonrandomized Study of Long-Term Antiarrhythmic Drug Therapy in Patients With Tachyarrhythmias : Japanese Antiarrhythmics Long-Term Study-2 (JALT-2 Study)
- The Genetic Factor in Pulmonary Arterial Hypertension(Diagnosis and Treatment of Pulmonary Hypertension, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 迷走神経刺激心房細動誘発モデルにおけるKチャネル遮断薬nifekalantとazimilideの薬理学的効果の比較
- 迷走神経刺激心房細動誘発モデルにおける刺激強度と電気生理学的変化の関連
- Discordant Temporal Changes in Electrophysiological Properties during Electrical Remodeling and Its Recovery in the Canine Atrium
- Radiosurgical Treatment Planning for Intracranial AVM Based on Images Generated by Principal Component Analysis : A Simulation Study
- Efficacy and Safety of Intravenous Amiodarone Infusion in Japanese Patients with Hemodynamically Compromised Ventricular Tachycardia or Ventricular Fibrillation
- Influence of photon scattering and attenuation on ROI analysis in brain perfusion single-photon emission tomographic imaging of normal subjects
- Marked Improvement with Sildenafil in a Patient with Primary Pulmonary Hypertension Unresponsive to Epoprostenol
- Comparison of image reconstruction algorithms in myocardial perfusion scintigraphy
- Anisotropic conduction properties: Assessment by high-resolution optical mapping in canine atria
- Absent myocardial accumulation of two different radioiodinated pentadecanoic acids
- Regional myocardial stretch induces the ST segment elevation in normal canine hearts in vivo
- Tetrathiaselenepin Ring Fused to Benzene and Naphthalene
- Macrocyclic Compounds Having Sulfide Moieties Derived from o-Terphenyl
- Structure and Electrochemical Property of Novel 1,4-Diselenins
- Efficient Synthesis, Structure, and Redox Reactions of 1,4,6,9-Tetraisopropylchalcogenanthrenes
- Synthesis of New Pentathiepin and Dithiatriselenepin Fused to Ferrocene via Dithiametallacycles
- 含硫黄,セレン,テルル複素5員環分子群を用いた可逆単電子酸化還元システムの構築
- Design of Reversible Low Redox Potential Systems Using Five-Membered Trichalcogenaheterocycles Containing Heavy Chalcogens ; Sulfur, Selenium, and Tellurium
- Preparation of Functionalized Thianthrenes and Their Higher Related Compounds by Photolysis of Benzotrithiole Derivatives
- Generation and Detection of a Dithia Dication Derived from 4,9-Diethyl-[1,4]dihydrodithiino[5,6-f]benzotrithiole 5-Oxide and Its Disproportionation
- Preparation and Conformational Analysis of 6,10-Diethyl[1,2,3]trithiolo-[4,5-h]benzopentathiepin Monoxides : Isolation and Optical Properties of Chiral Benzopentathiepin Derivatives
- First Preparation and Structural Determination of Optically Pure Cyclic Polysulfides, 6, 10-Diethyl Trithiolo[h]benzopentathiepin Monooxides
- Synthesis and Unique Packing Structure by X-Ray Analysis of New Types of Stable Trithioles Bound to Fused Aromatic Systems
- Synthesis, Structure, and Oxidation of Novel 4,7-Disubstituted Benzotrithioles. Formation and Characterization of Radical Cations with 11πElectron Framework
- Link Between SCN5A Mutation and the Brugada Syndrome ECG Phenotype : Simulation Study
- Men's Health Study : Epidemiology of Erectile Dysfunction and Cardiovascular Disease
- -0392-EFFECTS OF SYMPATHETIC STIMULATION ON EPICARDIAL ACTIVATION AND INDUCIBILITY OF VENTRICULAR TACHYARRHYTHMIAS IN A 7-DAY-OLD CANINE INFARCTION MODEL
- Parachute mitral valve incidentally diagnosed in an adult patient with hypertension
- Antithrombotic Therapy in Atrial Fibrillation : Evaluation and Positioning of New Oral Anticoagulant Agents
- Tumor Necrosis Factor-α Converting Enzyme Inactivation Ameliorates High-Fat Diet-Induced Insulin Resistance and Altered Energy Homeostasis
- Guidelines for Risks and Prevention of Sudden Cardiac Death (JCS 2010) : Digest Version
- Randomized, Multicenter, Warfarin-Controlled Phase II Study of Edoxaban in Japanese Patients With Non-Valvular Atrial Fibrillation
- Erratum for "A 19-year-old Man with Myocardial Infarction and Sitosterolemia [Intern. Med. 2003, 42, 591-594]"