Contribution of Nitric Oxide, Angiotensin II and Superoxide Dismutase to Exercise-induced Attenuation of Blood Pressure Elevation in Spontaneously Hypertensive Rats.
スポンサーリンク
概要
- 論文の詳細を見る
Moderate chronicexercise attenuates the elevation of blood pressure in young spontaneously hypertensive rats. In order to elucidate the physiological process of the effects of exercise, we examined the involvement of nitric oxide, angiotensin II, and superoxide dismutase in this process. Rats were exercised by voluntary running in a wheel-cage for 10 weeks. Systolic blood pressure in the exercised rats (195±4 mmHg, n=27) was significantly (p<0.05) lower than in the post-control rats (212±3 mmHg, n=28). The concentration of total plasma nitrite was significantly higher in exercised rats (14.9±1.5μmol l-1) than in the post-control rats (9.9±0.7 μmol l-1, p<0.05). Superoxide dismutase activity in the exercised rats was significantly higher (p<0.05) than in the post-control rats (thoracic aorta: 4.6±0.3 U mg protein-1 vs 3.6±0.3 U mg protein -1, heart: 12.7±0.6 U mg protein-1 vs 10.2±0.6 U mg protein-1, p<0.05). The plasma angiotensin II concentration was higher in the post-control rats (74.4±14.0 pg mL-1) than in the exercised rats (45.0±6.4 pg mL -1, p<0.05), and in the pre-control rats (47.2 ±6.0 pg mL-1). The results suggest that exercise acts to decrease the level of superoxide by increasing superoxide dismutase activity in the aorta and heart and to decrease levels of angiotensin II, both of which, in turn, increase the effective concentration of nitric oxide. We conclude that the combination of these effects with the increased NO formation resulted in the low blood pressure seen in the exercised rats.
- International Heart Journal刊行会の論文
著者
-
Ohmori Daijiro
Department Of Chemistry Juntendo University School Of Medicine
-
Yamakura Fumiyuki
Department Of Chemistry Juntendo University School Of Health Care And Nursing
-
OHMORI Daijiro
Department of Chemistry, Juntendo University School of Medicine
-
Kohno Hiroshi
the School of Health and Sports Science
-
Furukawa Satoshi
the School of Health and Sports Science
-
Naito Hisashi
the School of Health and Sports Science
-
Minamitani Kazutoshi
the School of Health and Sports Science
関連論文
- Two Tandemly Arranged Ferredoxin Genes in the Hydrogenobacter thermophilus Genome : Comparative Characterization of the Recombinant [4Fe-4S] Ferredoxins
- Nitrated and Oxidized Products of a Single Tryptophan Residue in Human Cu,Zn-Superoxide Dismutase Treated with Either Peroxynitrite-Carbon Dioxide or Myeloperoxidase-Hydrogen Peroxide-Nitrite
- Thermococcus profundus 2-Ketoisovalerate Ferredoxin Oxidoreductase, a Key Enzyme in the Archaeal Energy-Producing Amino Acid Metabolic Pathway
- Characterization and Cloning of an Extremely Thermostable, Pyrococcus furiosus-Type 4Fe Ferredoxin from Thermococcus profundus
- Ascaris suum NADH-methemo(myo)globin reductase systems recovering differential functions of hemoglobin and myoglobin, adapting to environmental hypoxia
- Indolepyruvate ferredoxin oxidoreductase : An oxygen-sensitive iron-sulfur enzyme from the hyperthermophilic archaeon Thermococcus profundus(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
- Indolepyruvate ferredoxin oxidoreductase : An oxygen-sensitive iron-sulfur enzyme from the hyperthermophilic archaeon Thermococcus profundus
- Contribution of Nitric Oxide, Angiotensin II and Superoxide Dismutase to Exercise-induced Attenuation of Blood Pressure Elevation in Spontaneously Hypertensive Rats.