Effects of Acute Exercise on Fibrinolysis and Coagulation in Patients With Coronary Artery Disease
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概要
- 論文の詳細を見る
Acute physical exertion may trigger an acute coronary syndrome. Furthermore, acute physical exercise may influence hemostatic markers in healthy individuals. However, the effect of acute exercise on blood fibrinolysis and coagulation in patients with coronary artery disease (CAD) is still not well understood. Nineteen untrained patients with angiographically proven CAD (age, 58 ± 9 years, 12 males), and 25 age- and sex-matched controls without CAD (age, 56 ± 6 years, 16 males) underwent a treadmill exercise test. Global fibrinolytic capacity (GFC) and prothrombin fragment 1 + 2 (F 1 + 2) levels were measured before exercise, at peak exercise, and 2 hours after recovery. There were no differences between the groups with respect to left ventricular ejection fraction, history of hypertension, body mass index, and serum lipids. Before exercise, GFC was significantly lower in patients with CAD when compared with controls (1.40 ± 0.43 versus 3.28 ± 1.19 μg/mL, respectively; P < 0.001). In patients with CAD, F 1 + 2 levels were significantly higher than those of controls (1.15 ± 0.43 versus 0.79 ± 0.10 nmol/L, respectively; P = 0.002). In both study groups, GFC levels increased significantly at peak exercise and decreased to baseline values 2 hours after recovery. At peak exercise, F 1 + 2 levels significantly increased in both study groups. However, while F 1 + 2 levels of controls decreased to baseline values 2 hours after recovery (0.79 ± 0.10 versus 0.80 ± 0.10 nmol/L; P > 0.05), F 1 + 2 levels of patients with CAD were still significantly elevated (1.15 ± 0.43 versus 1.84 ± 0.06 nmol/L; P = 0.002). Acute exercise increases coagulation and fibrinolysis both in untrained subjects with and without CAD. However, in patients with CAD, the equilibrium between fibrinolysis and coagulation during peak exercise is disturbed in favor of coagulation after recovery.
著者
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HAZNEDAROGLU Ibrahim
Department of Haematology, Hacettepe University Medical School
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Atalar Enver
Department Of Cardiology Hacettepe University School Of Medicine
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OZER Necla
Department of Cardiology, Hacettepe University School of Medicine
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AKSOYEK Serdar
Department of Cardiology, Hacettepe University School of Medicine
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OVUNC Kenan
Department of Cardiology, Hacettepe University School of Medicine
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OZMEN Ferhan
Department of Cardiology, Hacettepe University School of Medicine
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Aytemir Kudret
Department Of Cardiology Hacettepe University School Of Medicine
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TOKGOZOGLU Lale
Department of Cardiology, Hacettepe University Faculty of Medicine
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OTO Ali
Department of Cardiology, Hacettepe University, Faculty of Medicine
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Acil Tayfun
Department of Cardiology, Baskent University Faculty of Medicine
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Kaya Baris
Department of Cardiology, Hacettepe University School of Medicine
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Kes Sirri
Department of Cardiology, Hacettepe University School of Medicine
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Sahiner Levent
Department of Cardiology, Hacettepe University School of Medicine
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Nazli Nasih
Department of Cardiology, Hacettepe University School of Medicine
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